835915-18-9
Carbamic acid, [(2R)-2-amino-3-phenylpropyl]-, phenylmethyl ester,monohydrochloride
CAS: 835915-18-9
Molecular Formula: C17H21ClN2O2
835915-18-9 - Names and Identifiers
835915-18-9 - Physico-chemical Properties
| Molecular Formula | C17H21ClN2O2 |
| Molar Mass | 320.82 |
835915-18-9 - Introduction
Carbamic acid, [(2R)-2-amino-3-phenylpropyl]-, phenylmethyl ester,monohydrochloride is an organic compound with the chemical formula C26H28N2O2 · HCl. The following is an introduction to its nature, use, formulation and safety information:
Nature:
-Appearance: White crystal or crystalline powder
-Melting point: 134-137°C
-Solubility: soluble in acid, slightly soluble in alcohol and chloroform, almost insoluble in water
-Molecular weight: 444.02g/mol
Use:
Carbamic acid, [(2R)-2-amino-3-phenylpropyl]-, phenylmethyl ester,monohydrochloride is mainly used as an amino protective agent in organic synthesis. It can prevent unnecessary interference of the amine group during the reaction process, and can reduce the amine group by deprotection operation when necessary.
Preparation Method:
Carbamic acid, [(2R)-2-amino-3-phenylpropyl]-, phenylmethyl ester,monohydrochloride can be prepared by the following steps:
1. (R)-2-amino -3-phenyl propanol reacts with benzoic acid and dimethyl dehydrogenase (DCC) in dichloromethane to produce (R)-2-benzoic acid oxyethyl ester -3-phenyl propanol.
2. The resulting ester reacts with N-catecarbime under alkaline conditions to generate N-Cbz-(R)-2-benzoic acid oxyethyl ester -3-phenyl propanol. The product is then reacted with trichloroformic acid to produce the Carbamic acid, [(2R)-2-amino-3-phenylpropyl]-, phenylmethyl ester,monohydrochloride.
Safety Information:
- Carbamic acid, [(2R)-2-amino-3-phenylpropyl]-, phenylmethyl ester,monohydrochloride safety data is limited, please read relevant literature and safety data sheets provided by production suppliers before use.
-Laboratory safety procedures and proper handling of chemicals must be followed.
-Wear appropriate personal protective equipment such as protective gloves, safety glasses and protective clothing when exposed to the compound.
-During handling and storage, avoid contact with oxidants, strong acids and strong bases to avoid harmful gases and vapors.
-Avoid inhalation, ingestion or contact with skin due to lack of reliable toxicological data. In the event of an accident, appropriate first aid measures should be taken immediately and medical assistance should be sought.
Nature:
-Appearance: White crystal or crystalline powder
-Melting point: 134-137°C
-Solubility: soluble in acid, slightly soluble in alcohol and chloroform, almost insoluble in water
-Molecular weight: 444.02g/mol
Use:
Carbamic acid, [(2R)-2-amino-3-phenylpropyl]-, phenylmethyl ester,monohydrochloride is mainly used as an amino protective agent in organic synthesis. It can prevent unnecessary interference of the amine group during the reaction process, and can reduce the amine group by deprotection operation when necessary.
Preparation Method:
Carbamic acid, [(2R)-2-amino-3-phenylpropyl]-, phenylmethyl ester,monohydrochloride can be prepared by the following steps:
1. (R)-2-amino -3-phenyl propanol reacts with benzoic acid and dimethyl dehydrogenase (DCC) in dichloromethane to produce (R)-2-benzoic acid oxyethyl ester -3-phenyl propanol.
2. The resulting ester reacts with N-catecarbime under alkaline conditions to generate N-Cbz-(R)-2-benzoic acid oxyethyl ester -3-phenyl propanol. The product is then reacted with trichloroformic acid to produce the Carbamic acid, [(2R)-2-amino-3-phenylpropyl]-, phenylmethyl ester,monohydrochloride.
Safety Information:
- Carbamic acid, [(2R)-2-amino-3-phenylpropyl]-, phenylmethyl ester,monohydrochloride safety data is limited, please read relevant literature and safety data sheets provided by production suppliers before use.
-Laboratory safety procedures and proper handling of chemicals must be followed.
-Wear appropriate personal protective equipment such as protective gloves, safety glasses and protective clothing when exposed to the compound.
-During handling and storage, avoid contact with oxidants, strong acids and strong bases to avoid harmful gases and vapors.
-Avoid inhalation, ingestion or contact with skin due to lack of reliable toxicological data. In the event of an accident, appropriate first aid measures should be taken immediately and medical assistance should be sought.
Last Update：2024-04-10 22:29:15
