83602-39-5
Cyclosporin H
CAS: 83602-39-5
Molecular Formula: C62H111N11O12
83602-39-5 - Names and Identifiers
83602-39-5 - Physico-chemical Properties
| Molecular Formula | C62H111N11O12 |
| Molar Mass | 1202.61 |
| Density | 1.016±0.06 g/cm3(Predicted) |
| Melting Point | 148-151°C |
| Boling Point | 1293.8±65.0 °C(Predicted) |
| Flash Point | 729.1°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | powder |
| Color | white to beige |
| pKa | 13.32±0.70(Predicted) |
| Storage Condition | -20°C |
| Refractive Index | 1.468 |
| In vitro study | The cyclic undecapeptide, cyclosporin H, is a potent inhibitor of formyl-Met-Leu-Phe (FMLP)-induced superoxide anion (O2-) formation in human neutrophils. Cyclosporin H inhibits FMLP binding in HL-60 membranes with a K i of 0.1 μM. Cyclosporin H inhibits activation by FMLP of high affinity GTPase (the enzymatic activity of alpha-subunits of heterotrimeric regulatory guanine nucleotide-binding proteins) in HL-60 membranes with a K i of 0.79 μM. Cyclosporin H inhibits the stimulatory effects of FMLP on cytosolic Ca 2+ concentration ([Ca 2+ ]i), O2- formation, and beta-glucuronidase release with K i values of 0.08, 0.24, and 0.45 μM, respectively. |
| In vivo study | Cyclosporin H (5 mg/kg; i.p.; before LPS or HCl challenge) attenuats lung injury induced by LPS or HCl (a lung injurymodel). |
83602-39-5 - Risk and Safety
| HS Code | 29420000 |
83602-39-5 - Reference Information
| biological activity | Cyclosporin H is a selective potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H is a Virus transduction enhancer that enhances slow Virus transduction 10-fold in human umbilical cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H showed additive effects when used in combination with rapamycin (HY-10219) or prostaglandin E2 (HY-101952). Cyclosporin H lacks the immunosuppressive activity of Cyclosporin A. |
Last Update：2024-04-09 21:01:54
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Product Name: Cyclosporin Impurity 8（Cyclosporin H） Visit Supplier Webpage Request for quotationCAS: 83602-39-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Cyclosporin H Visit Supplier Webpage Request for quotationCAS: 83602-39-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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