84371-65-3
mifepristone
CAS: 84371-65-3
Molecular Formula: C29H35NO2
84371-65-3 - Names and Identifiers
| Name | mifepristone |
| Synonyms | RU486 ru486-6 MIFEGYNE RU-38486 MIFEPRISTONE mifepristone ra-4,9-dien-3-one Mifepriston Dianhydride 11BETA-[4-(DIMETHYLAMINO)PHENYL]-17BETA-HYDROXY-17-(1-PROPYNYL)ESTRA-4,9-DIEN-3-ONE (11BETA,17BETA)-11-(4-(DIMETHYLAMINO)PHENYL)-17-HYDROXY-17-(1-PROPYNYL)ESTRA-4,9-DIEN-3-ONE (11R,13S,17S)-11-(4-dimethylaminophenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one |
| CAS | 84371-65-3 |
| EINECS | 617-559-7 |
| InChI | InChI=1/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24?,25-,26?,28+,29+/m1/s1 |
| InChIKey | VKHAHZOOUSRJNA-GCNJZUOMSA-N |
84371-65-3 - Physico-chemical Properties
| Molecular Formula | C29H35NO2 |
| Molar Mass | 429.6 |
| Density | 1.0731 (rough estimate) |
| Melting Point | 195-198°C |
| Boling Point | 544.13°C (rough estimate) |
| Specific Rotation(α) | D20 +138.5° (c = 0.5 in chloroform) |
| Flash Point | 334°C |
| Water Solubility | 474.8ug/L(22.5 ºC) |
| Solubility | ethanol: 50 mg/mL. It is soluble in methanol or dichloromethane, dissolved in ethanol or ethyl acetate, and almost insoluble in water. |
| Vapor Presure | 1.14E-16mmHg at 25°C |
| Appearance | Pale yellow solid |
| Color | Yellow |
| Merck | 14,6186 |
| pKa | 12.94±0.60(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Sensitive | Sensitive to heat |
| Refractive Index | 1.6290 (estimate) |
| MDL | MFCD00867226 |
| Physical and Chemical Properties | Melting point 150 °c. [Α] D20 138.5 °(C = 0.5, chloroform). Acute toxicity LD50 mice (g/kg):>2.6 intraperitoneal injection. |
| Use | Used as an anti-early pregnancy drug |
84371-65-3 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R60 - May impair fertility R61 - May cause harm to the unborn child |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
| RTECS | KG2955000 |
| HS Code | 29372900 |
84371-65-3 - Nature
Open Data Verified Data
light yellow crystalline powder, odorless, tasteless. Melting point 150 °c. Soluble in methanol or methylene chloride, soluble in ethanol or ethyl acetate, almost insoluble in water.
Last Update：2024-01-02 23:10:35
84371-65-3 - Preparation Method
Open Data Verified Data
with 4,9 estradiene 3 ,17-= ketone as raw material, and propyne magnesium bromide Grignard reagent reaction, propynyl was introduced at position 17, this is followed by selective epoxidation of the 5-position olefinic bond, followed by reaction with P-dimethylaminophenyl magnesium bromide in tetrahydrofuran containing a copper bromide-dimethyl sulfide complex, and treatment to give mifepristone. Or 4,9 estradiene -3,17-ketone as raw material, protection of 3 carbonyl, and then first epoxidation, and then in 17 propynyl, P-dimethylaminophenyl was introduced at position 11 and finally hydrolyzed to give mifepristone.
Last Update：2022-01-01 09:23:55
84371-65-3 - Standard
Authoritative Data Verified Data
This product is 11B-[4-(N,N-dimethylamino) small phenyl]-17b-hydroxy-l7a-(1-propynyl)-Estrin -4, 9-dien-3-one. Calculated as the dried product, the content of C29H35N02F was less than 98.5%.
Last Update：2024-01-02 23:10:35
84371-65-3 - Trait
Authoritative Data Verified Data
- This product is light yellow crystalline powder; Odorless, tasteless.
- This product is soluble in methanol or two gas methane, dissolved in ethanol or ethyl acetate, almost insoluble in water.
melting point
The melting point of this product (General 0612) is 192~196°C.
specific rotation
take this product, precision weighing, add methylene chloride to dissolve and quantitatively dilute the solution containing about 5mg per lml, according to the law (General 0621), the specific rotation was 124 ° to 129 °.
Last Update：2022-01-01 11:54:12
84371-65-3 - Introduction
Mifepristone is an abnormally active progesterone receptor and glucocorticoid receptor antagonist with IC50 of 0.2nM and 2.6 nM respectively.
Last Update：2022-10-16 17:29:19
84371-65-3 - Use
Open Data Verified Data
developed by the French company Roussel-Uclaf, launched in 1988. New anti-progestin and anti-glucocorticoid activity. Mifepristone has the effect of anti-implantation of fertilized eggs, inducing menstruation and promoting cervical ripening. The mechanism of promoting menstruation and stopping pregnancy is mainly through competition for progesterone receptor in endometrium (decidua), blocking the effect of progesterone. And progesterone receptor affinity is 5 times stronger than progesterone. It is used for anti-early pregnancy, promoting menstruation and stopping pregnancy, intrauterine induction of fetal death, etc.
Last Update：2022-01-01 09:23:56
84371-65-3 - Differential diagnosis
Authoritative Data Verified Data
- take this product, dissolve and dilute with ethanol to make a solution containing about 10ug per lml, and measure by UV-Vis spectrophotometry (General 0401), there is a maximum absorption at wavelengths of 304nm and 260mn.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 1141).
Last Update：2022-01-01 11:54:12
84371-65-3 - Safety
Open Data Verified Data
mice injected intraperitoneally with LD50( g/kg):>2.6.
Last Update：2022-01-01 09:23:56
84371-65-3 - Exam
Authoritative Data Verified Data
Related substances
take this product, add methanol to dissolve and dilute to make a solution containing about 0.5mg per 1 ml as a test solution; Take 2ml for precision measurement and put it in a 100ml measuring flask, methanol was added to dilute to the scale, shake, as a control solution. According to the method of high performance liquid chromatography (General rule 0512), silica gel bonded with eighteen alkyl silane was used as the filler, methanol-water-triethylamine (75:25:0.05) was used as the mobile phase, and the detection wavelength was 304mn. The number of theoretical plates is not less than 2000 according to the mifepristone peak. Take 10 u1 of the test solution and the control solution respectively, inject the human liquid chromatograph, record the chromatogram to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (1.0%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (2.0%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
Last Update：2022-01-01 11:54:13
84371-65-3 - Content determination
Authoritative Data Verified Data
take this product about 0.3g, precision weighing, add glacial acetic acid dissolved in 20ml, add crystal violet indicator solution 1 drop, with perchloric acid titration solution (0.1 mol/L) titration to the solution is blue-green, and the result of the titration is corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 42.96mg of C29H35N02.
Last Update：2022-01-01 11:54:13
84371-65-3 - Category
Authoritative Data Verified Data
Anti-early pregnancy drugs.
Last Update：2022-01-01 11:54:14
84371-65-3 - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:54:14
84371-65-3 - MifeisitongPian
Authoritative Data Verified Data
This product contains mifepristone (C29H35N02F) should be labeled the amount of 90.0% to 110.0%.
trait
This product is a yellowish tablet.
identification
take an appropriate amount of the fine powder of this product (about 20mg equivalent to mifepristone) and show the same result according to the identification (1) Test under the item of mifepristone.
examination
- Related substances take an appropriate amount of fine powder of this product (about 50mg equivalent to mifepristone), weigh it accurately, put it in a 100ml measuring flask, add an appropriate amount of methanol, shake it for 30 minutes to dissolve mifepristone, dilute to the scale with methanol, shake, filter, and take the filtrate as a test solution. The test was carried out according to the method under mifepristone related substances. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (1.0%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (2.0%).
- Content uniformity take 1 tablet of this product, put it in a lOOml(lOmg specification) or 250ml(25mg specification) measuring flask, add 0.lmol/L hydrochloric acid solution appropriate amount, shake to dissolve mifepristone, with 0. Dilute 1 mol/L hydrochloric acid solution to the scale, shake well, filter, Take 5ml of continuous filtrate accurately, put it in 50ml measuring flask, use 0.lmol/L hydrochloric acid solution diluted to the scale, shake, according to UV-visible spectrophotometry (General 0401), determination of absorbance at the wavelength of 310mn, the content shall be calculated according to the absorption coefficient of C29H35N02 as 463, and shall comply with the regulations (General 0941).
- dissolution of this product, according to the dissolution and release determination method (General 0931 first method), with 0.100 ml of 1 mol/L hydrochloric acid solution is the dissolution medium, and the rotation speed is revolutions per minute. After 30 minutes, 15ml of the solution is taken, filtered, and 10ml of the continued filtrate is taken in a precise amount, quantitative dilution with dissolution medium to prepare a solution containing about 10ug of mifepristone per 1 ml, according to UV-visible spectrophotometry (General 0401), the absorbance was measured at the wavelength of 310nm, the elution amount of each tablet was calculated as the absorption coefficient of C29H35N02F was 463. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (about 50mg equivalent to mifepristone), put it in a 100ml measuring flask, add 0.lmol/L hydrochloric acid solution appropriate amount, shake to dissolve mifepristone, and 0. Dilute 1 mol/L hydrochloric acid solution to the scale, shake well, filter, take 2ml of continuous filtrate accurately, put it in a 100ml measuring flask, use 0.lmol/L hydrochloric acid solution diluted to the scale, shake, according to UV-visible spectrophotometry (General 0401), at the wavelength of 310nm absorbance, the absorption coefficient of C29H35N02 was calculated to be 463.
category
with mifepristone.
specification
(l)lOmg (2)25mg (3)0.2g
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:54:15
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Product Name: mifepristone Request for quotation
CAS: 84371-65-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 84371-65-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
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Product Name: Mifepristone Visit Supplier Webpage Request for quotationCAS: 84371-65-3
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