85-19-8
5-chloro-2-hydroxybenzophenone
CAS: 85-19-8
Molecular Formula: C13H9ClO2
85-19-8 - Names and Identifiers
| Name | 5-chloro-2-hydroxybenzophenone |
| Synonyms | benzophenone-7 Benzophenone-7 2-benzoyl-4-chlorophenol chlorohydroxybenzophenone 5-chloro-2-hydroxy-benzophenon 5-chloro-2-hydroxybenzophenone 3-chloro-6-hydroxybenzophenone benzophenone,5-chloro-2-hydroxy- (5-chloro-2-hydroxyphenyl)phenyl-methanon (5-chloro-2-hydroxyphenyl)(phenyl)methanone benzophenone-7,5-chloro-2-hydroxybenzophenone |
| CAS | 85-19-8 |
| EINECS | 201-592-5 |
| InChI | InChI=1/C13H9ClO2/c14-10-6-7-12(15)11(8-10)13(16)9-4-2-1-3-5-9/h1-8,15H |
85-19-8 - Physico-chemical Properties
| Molecular Formula | C13H9ClO2 |
| Molar Mass | 232.66 |
| Density | 1.307±0.06 g/cm3(Predicted) |
| Melting Point | 96-98°C(lit.) |
| Boling Point | 147-149 °C(Press: 0.3 Torr) |
| Flash Point | 168.8°C |
| Vapor Presure | 1.52E-05mmHg at 25°C |
| Maximum wavelength(λmax) | ['430nm(CH3CN)(lit.)'] |
| pKa | 7.49±0.43(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.623 |
85-19-8 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| HS Code | 29147000 |
85-19-8 - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| Application | 2-hydroxy-5-chlorobenzophenone is an intermediate in organic synthesis and a pharmaceutical intermediate, can be used in laboratory research and development process and chemical production process. |
| preparation | add 4-chlorophenyl benzoate (250g, 23.3 mmol) to a 100 ml round bottom flask and anhydrous aluminum chloride (16.7g,125 mmol,1.25eq). The thawed reaction mixture was stirred slowly at 160-180°C for 3 hours. The mixture was cooled to room temperature. The mixture was quenched with ice-cold water (170 mL) and 10% aqueous hydrochloric acid (85 mL), and dichloromethane (200 mL) was added to the mixture and shaken well until complete dissolution. The solution was transferred to a separatory funnel and the aqueous layer was separated from the organic layer and extracted twice more (2x 200 mL). The combined organic layers were concentrated to about 150 mL under reduced pressure. The mixture was transferred to a separatory funnel and the mixture was extracted with 2.5% sodium hydroxide solution (4x 250 mL). The combined aqueous alkaline layers were acidified with 10% sulfuric acid (pH ~ 1, about 300 mL), the crude precipitate was filtered off and the filtrate was dried in air. After purification with activated carbon, crude crystals were crystallized from methanol to obtain 2-hydroxy-5-chlorobenzophenone. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:04:16
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