85-61-0
Coenzyme a
CAS: 85-61-0
Molecular Formula: C21H36N7O16P3S
85-61-0 - Names and Identifiers
85-61-0 - Physico-chemical Properties
| Molecular Formula | C21H36N7O16P3S |
| Molar Mass | 767.53 |
| Density | 1.96±0.1 g/cm3(Predicted) |
| Solubility | Soluble in water or saline, insoluble in ethanol, ether or acetone. |
| Merck | 13,2491 |
| BRN | 77809 |
| pKa | 9.6 (thiol); pK 6.4 (secondary phosphate); pK 4.0 (adenine NH3+) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Refractive Index | 1.736 |
| MDL | MFCD06795839 |
| Physical and Chemical Properties | This product is white or yellowish powder, similar to garlic odor, moisture absorption. Soluble in water or saline, insoluble in ethanol, ether or acetone. Both nucleotides and thiols, is a strong acid. |
| Use | For the treatment of atherosclerosis, chronic arteritis, myocardial infarction, myocarditis, various liver diseases |
85-61-0 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 1-10 |
| TSCA | Yes |
85-61-0 - Reference
| Reference Show more | 1. Wang Jie, Wang dujun, Li Fengwei, etc. Optimization of conditions for enrichment of γ-aminobutyric acid and flavonoids from Salicornia seed germination and study on key enzyme activities [J]. Food Research and Development, 2019, v.40;No.372(23):66-73. 2. [IF = 5.279] Xue-Ning Wang et al."Diacerin as a proposed Acyl Donor in Biosynthetic Acetyl-CoA and Glycosyl estors Mediated by a Multifunctional Maltose O-Acetyltransferase from eschichia coli." J Agr Food Chem. 2021;69(23):6623-6635 |
85-61-0 - Nature
Open Data Verified Data
- This product is a white or yellowish powder with hygroscopicity. Soluble in water or saline, insoluble in ethanol, ether or acetone. Both nucleotides and thiols, is a strong acid.
- This product is a normal component of the body. Its molecule consists of 3 ',5' adenosine diphosphate (ADP), pantothenic acid and cysteine. It is a coenzyme of various acetylation reactions in the body, involved in the metabolism of sugar, fat and protein and the detoxification process of antibodies, including the formation of citric acid, the oxidation of pyruvic acid, the synthesis and oxidation of fatty acids, triglycerides, synthesis of cholesterol and phospholipids, acetylation of amines, cholesterol and glucosamine, etc.
Last Update：2024-01-02 23:10:35
85-61-0 - Preparation Method
Open Data Verified Data
- resin adsorption method using pig liver as raw material.
- an extraction method using yeast as a raw material.
- microbial biosynthesis.
Last Update：2022-01-01 11:12:56
85-61-0 - Use
Open Data Verified Data
- for leukopenia, idiopathic thrombocytopenic purpura and functional low-grade fever. And for fatty liver, hepatitis, hepatic coma, coronary arteriosclerosis, myocardial infarction, nephrotic syndrome, uremia, neonatal hypoxia, diabetes and acidosis; And for the protection of radioactive damage, delay the development of muscle atrophy.
- preparation injection is a sterile lyophilized preparation of coenzyme A, and an appropriate amount of cysteine hydrochloride, calcium gluconate, hydrolyzed gelatin and the like are added as stabilizers and excipients.
Last Update：2022-01-01 11:12:56
85-61-0 - Safety
Open Data Verified Data
shade, seal, and store in a cool place.
Last Update：2022-01-01 11:12:56
85-61-0 - Trait
White or yellowish powder.
Last Update：2023-08-16 21:32:38
85-61-0 - Source
Yeast
Last Update：2023-08-16 21:32:38
85-61-0 - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | Coenzyme A(Coenzyme A), which is A Coenzyme for acetylation reaction in vivo, fat and protein metabolism plays an important role, in which the promotion of fat metabolism is more important. This product can activate the metabolism of substances in the body, strengthen the oxidation of substances in the body and supply energy. Mainly used for leukopenia and idiopathic thrombocytopenic purpura, on fatty liver, acute and chronic hepatitis, coronary sclerosis, chronic arteritis, myocardial infarction, chronic renal dysfunction caused by nephrotic syndrome and uremia, neonatal hypoxia, diabetes and acidosis can be used as adjuvant therapy. |
| pharmacological effects | coenzyme A is derived from fresh yeast, which is a coenzyme for acetyl reaction in vivo, it can be combined with acetate to form acetyl CoA, enter the oxidation process, and play an important role in the metabolism of sugar, protein and fat; In vivo tricarboxylic acid cycle, synthesis of acetylcholine, storage of liver glycogen, the reduction of cholesterol and the regulation of plasma fat content are closely related to coenzyme A. However, at present, it is also believed that pantothenic acid, the main component of coenzyme A, is not deficient in the human body, and the general patient does not need to supplement coenzyme A, and exogenous coenzyme A is a macromolecule and is not easy to enter the cell through the cell membrane, so its curative effect is suspicious. |
| Source | coenzyme A is derived from fresh yeast and consists of pantothenic acid, adenine, ribose, cysteamine and phosphoric acid. |
| Use | for leukopenia, primary thrombocytopenic purpura and functional low-grade fever. And for fatty liver, hepatitis, hepatic coma, coronary arteriosclerosis, myocardial infarction, nephrotic syndrome, uremia, neonatal hypoxia, diabetes and acidosis; And for the protection of radioactive damage, delay the development of muscle atrophy. coenzyme. Is an important factor in the regulation of sugar, fat and protein metabolism. biochemical research; Clinical for the treatment of leukopenia, primary thrombocytopenic purpura, functional low fever and other diseases. |
| production method | fresh yeast is extracted with boiling water, centrifuged, the solution is adjusted to pH to acid, and eluted with acetone and concentrated ammonia water, the COA coarse crystal was obtained and purified by adsorption on a cation exchange resin column. The product was extracted from fresh yeast. The process steps are as follows: fresh pressed yeast [wall-broken] clear solution [primary adsorption] resin adsorbate [elution] primary eluent [secondary adsorption] Activated Carbon adsorbate [elution] Secondary eluent [concentration] concentrated solution [reduction] reducing solution [Complexation] Complex [purification] purified liquid [concentrated] concentrated liquid [precipitate] precipitate [dry] Coenzyme A |
Last Update：2024-04-09 15:16:53
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Product Name: COA Visit Supplier Webpage Request for quotationCAS: 85-61-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Coenzyme A Request for quotation
CAS: 85-61-0
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380
Wechat: 15387090420
CAS: 85-61-0
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380
Wechat: 15387090420
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