85-87-0
pyridoxamine
CAS: 85-87-0
Molecular Formula: C8H12N2O2
85-87-0 - Names and Identifiers
85-87-0 - Physico-chemical Properties
| Molecular Formula | C8H12N2O2 |
| Molar Mass | 168.19 |
| Density | 1.282±0.06 g/cm3(Predicted) |
| Melting Point | 193-193.5 °C |
| Boling Point | 460.1±40.0 °C(Predicted) |
| Flash Point | 232.1°C |
| Solubility | soluble in DMSO |
| Vapor Presure | 2.92E-09mmHg at 25°C |
| Appearance | Solid |
| Color | Pale Yellow |
| pKa | 9.98±0.10(Predicted) |
| Storage Condition | Hygroscopic, Refrigerator, under inert atmosphere |
| Stability | Hygroscopic |
| Refractive Index | 1.617 |
| Use | Pyridoxylamine are advanced glycation end products (AGE) and lipid end products (ALE) inhibitors that prevent diabetic-induced retinal vasculopathy. |
| In vitro study | Pyridoxylamine (PM), a member of the B 6 vitamer family, is a potent scavenger of reactive carbonyls, inhibiting the late stages of glycation reactions that lead to AGE formation. |
| In vivo study | Pyridoxylamine limits the formation of CML and CEL and cross-linking in skin collagen and, ultimately inhibits the development of nephropathy in STZ-diabetic rats. Pyridoxylamine does not appear to function as an antioxidant since it does not prevent lipid peroxidation reactions. At the same time, it does prevent protein modification by products of lipid peroxidation, including inhibiting formation of malondialdehyde and 4-hydroxynonenal adducts on protein in Zucker rats in vivo. |
85-87-0 - Reference
| Reference Show more | 1. [IF=4.27] Jieren Liao et al."GABA shunt contribution to flavonoid biosynthesis and metabolism in tea plants (Camellia sinensis)."Plant Physiol Bioch. 2021 Sep;166:849 |
85-87-0 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 5.945 ml | 29.727 ml | 59.453 ml |
| 5 mM | 1.189 ml | 5.945 ml | 11.891 ml |
| 10 mM | 0.595 ml | 2.973 ml | 5.945 ml |
| 5 mM | 0.119 ml | 0.595 ml | 1.189 ml |
Last Update：2024-01-02 23:10:35
85-87-0 - Reference Information
| pyridoxine | Vitamin B6(Vitamin B6), also known as pyridoxine, pyridoxal and pyridoxamine, in the body in the form of phosphate, is a water-soluble vitamin, light or alkali easily damaged, not high temperature. Vitamin B6 was named in 1936. Vitamin B6 is colorless crystals, soluble in water and ethanol, stable in acid, easy to destroy in the alkali, pyridoxine heat, pyridoxal and pyridoxamine is not high temperature resistant. The basic structure of vitamin B6 is 2-methyl-3-hydroxy-5-hydroxymethylpyridine including three forms: pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), both have the biological activity of vitamin B6, these three forms can be transformed into each other in the body, in animal tissues, in plants with pyridoxine. Vitamin B6 is soluble in water, quite stable to acid, easy to destroy in alkaline solution, easy to be destroyed by light in neutral solution, more stable to oxygen. Pyridoxal and pyridoxamine are relatively heat-labile, Pyridoxine is heat-resistant and has good stability during food processing and storage. |
| Source | vitamins in plants are present as pyridoxine, and animal products contain pyridoxamine and pyridoxal. Pyridoxine and its derivatives are widely distributed in yeast, cereals, liver and milk. |
| biological activity | Pyridoxylamine is an inhibitor of advanced glycation end products (AGEs) and lipidation end products (ALE), can prevent diabetes caused by retinal vascular disease. |
Last Update：2024-04-10 22:29:15
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Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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Product Name: pyridoxamine Visit Supplier Webpage Request for quotationCAS: 85-87-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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