850568-05-7

850568-05-7 - Names and Identifiers

Name	[5-Fluoro-2-(methoxycarbonyl)phenyl]boronic acid
Synonyms	AKOS BRN-0797 METHYL 2-BORONO-4-FLUOROBENZOATE 5-Fluoro-2-methoxycarboxyphenylboronic acid 2-Methoxycarbonyl-5-fluorophenylboronicacid 5-FLUORO-2-METHOXYCARBONYLPHENYLBORONIC ACID 5-Fluoro-2-Methoxycarbonylphenylboronic Acid benzoic acid, 2-borono-4-fluoro-, methyl ester 2-(METHOXYCARBONYL)-5-FLUOROPHENYLBORONIC ACID (5-FLUORO-2-METHOXYCARBONYL)BENZENEBORONIC ACID 5-Fluoro-2-(methoxycarbonyl)benzeneboronic acid [5-Fluoro-2-(methoxycarbonyl)phenyl]boronic acid
CAS	850568-05-7
InChI	InChI=1/C8H8BFO4/c1-14-8(11)6-3-2-5(10)4-7(6)9(12)13/h2-4,12-13H,1H3

850568-05-7 - Physico-chemical Properties

Molecular Formula	C8H8BFO4
Molar Mass	197.96
Density	1.33±0.1 g/cm3(Predicted)
Melting Point	146-148
Boling Point	363.1±52.0 °C(Predicted)
Flash Point	173.4°C
Vapor Presure	6.58E-06mmHg at 25°C
pKa	7.16±0.58(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.513

850568-05-7 - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Note	Irritant

850568-05-7 - Introduction

[5-Fluoro-2-(methoxycarbonyl)phenyl]boronic acid, also known as [5-Fluoro-2-(methoxycarbonyl)phenyl]boronic acid, is an organoboron compound. Its chemical formula is C8H8BFO4.

The following is a description of the nature, use, preparation and safety information of [5-Fluoro-2-(methoxycarbonyl)phenyl]boronic acid:

Nature:
-Appearance: White solid
-melting point: about 132-135 ℃
-Solubility: Soluble in common organic solvents (such as ether, chloroform, ethanol, etc.), insoluble in water

Use:
- [5-Fluoro-2-(methoxycarbonyl)phenyl]boronic acid is an important organic intermediate, which can be used as a catalyst and raw material for organic synthesis reactions, especially in the fields of medicine and pesticides.
-It has properties similar to phenylboronic acid derivatives and can be used in copper-catalyzed carbon-carbon bond formation reactions (such as Suzuki coupling reactions).

Preparation Method:
- [5-Fluoro-2-(methoxycarbonyl)phenyl]boronic acid can be obtained by reacting phenylboronic acid with methyl formate under alkaline conditions.
-The specific preparation method includes using lithium benzyl (LiBn) as a boron donor, reacting with 2-methoxyphenyl and 2-bromo-5-fluorobenzoic acid methyl ester.

Safety Information:
- [5-Fluoro-2-(methoxycarbonyl)phenyl] The specific toxicity and danger of boronic acid has not been publicly reported, but in general, as a chemical, it is necessary to strictly follow safe procedures.
-Avoid skin contact, inhalation or ingestion.
-Appropriate personal protective equipment such as gloves, glasses and protective clothing must be worn during use.
-If exposed or ingested, seek medical attention immediately.

Last Update：2024-04-09 02:00:48