851376-05-1
JNJ-18038683
CAS: 851376-05-1
Molecular Formula: C26H28ClN3O7
851376-05-1 - Names and Identifiers
| Name | JNJ-18038683 |
| Synonyms | JNJ-18038683 |
| CAS | 851376-05-1 |
851376-05-1 - Physico-chemical Properties
| Molecular Formula | C26H28ClN3O7 |
| Molar Mass | 529.97 |
| Solubility | Soluble in DMSO |
| Storage Condition | -20℃ |
| Use | JNJ-18038683 is a 5-HT7 receptor antagonist which has been shown to be effective in models of depression and to increase the latency to rapid eye movement (REM) sleep and decrease REM duration. JNJ-18038683 enhanced serotonin transmission, antidepressant-like behavior, and REM sleep suppression induced by citalopram in rodents. |
851376-05-1 - Reference
| Reference Show more | 1: Shelton J, Yun S, Losee Olson S, Turek F, Bonaventure P, Dvorak C, Lovenberg T, Dugovic C. Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity. Front Behav Neurosci. 2015 Jan 15;8:453. doi: 10.3389/fnbeh.2014.00453. PMID: 25642174; PMCID: PMC4295543. 2: Bonaventure P, Dugovic C, Kramer M, De Boer P, Singh J, Wilson S, Bertelsen K, Di J, Shelton J, Aluisio L, Dvorak L, Fraser I, Lord B, Nepomuceno D, Ahnaou A, Drinkenburg W, Chai W, Dvorak C, Sands S, Carruthers N, Lovenberg TW. Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder. J Pharmacol Exp Ther. 2012 Aug;342(2):429-40. doi: 10.1124/jpet.112.193995. Epub 2012 May 8. PMID: 22570363. |
851376-05-1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.887 ml | 9.434 ml | 18.869 ml |
| 5 mM | 0.377 ml | 1.887 ml | 3.774 ml |
| 10 mM | 0.189 ml | 0.943 ml | 1.887 ml |
| 5 mM | 0.038 ml | 0.189 ml | 0.377 ml |
Last Update：2024-01-02 23:10:35
851376-05-1 - Cell Experiment
HEK-293 cells stably expressing the rat 5-HT7 receptor are preincubated for 10 min with seven concentrations of JNJ-18038683 (10 μM-100 pM) followed by incubation with 100 nM of the agonist (5-HT). cAMP measurements are determined. SB-2699970 is used as the reference compound7receptor.
Last Update：2023-08-16 21:32:38
851376-05-1 - Animal Experiment
Mice[1]Rat telemetry experiments are performed. In brief, telemetric devices are implanted in the peritoneal cavity of rats. After a 7-day recovery period, body temperature is measured noninvasively by radiotelemetry. On the day of the experiment, the baseline is monitored for 60 min before drug injection. Rat core temperature is continuously recorded, before and after injection, and averaged over each 2-min collection period. JNJ-18038683 (0.09, 0.9, and 9.0 mg/kg) is administered orally 6 h before 5-CT (0.1 mg/kg, i.p.) administration or intraperitoneally (0.027, 0.09, 0.18, 0.27, and 0.9 mg/kg) 20 min before 5-CT (0.1 mg/kg i.p.) administration (n=5 in each group). Change in core body temperature is calculated for all animals by comparing baseline before dosing to the minimal temperature reached after drug administration.
Last Update：2023-08-16 21:32:38
Supplier List
Spot supply
Product Name: JNJ-18038683 Visit Supplier Webpage Request for quotationCAS: 851376-05-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: JNJ-18038683 Visit Supplier Webpage Request for quotationCAS: 851376-05-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History