856867-55-5
Tedizolid phosphate
CAS: 856867-55-5
Molecular Formula: C17H16FN6O6P
856867-55-5 - Names and Identifiers
856867-55-5 - Physico-chemical Properties
| Molecular Formula | C17H16FN6O6P |
| Molar Mass | 450.32 |
| Density | 1.75±0.1 g/cm3(Predicted) |
| Melting Point | >235°C (dec.) |
| Boling Point | 725.6±70.0 °C(Predicted) |
| Solubility | DMSO: ≥ 36 mg/mL |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 1.81±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Stability | Hygroscopic |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Tedizolid (TR-700) is the active part of the prodrug tedizolid phosphate (TR-701) and has activity against Gram-positive bacteria, including methicillin-resistant S. Aureus. Tedizolid is more than 4 times more potent in vitro to antagonize PRSP than linezolid. |
| In vivo study | Tedizolid has good permeability of lung epithelial mucus layer. Tedizolid phosphate is effective in antagonizing systemic infections in vivo by oral route or intravenous administration. Oral Tedizolid phosphate also effectively antagonized Pneumonia of the induction by the PSSP strain. |
856867-55-5 - Introduction
Tedizolid phosphate (phospheric Acid Trizolamine) is an inorganic compound with the chemical formula H3PO4 • C6H15N3. The following is a description of the nature, use, formulation and safety information of Tedizolid phosphate:
Nature:
-Appearance: Tedizolid phosphate is a colorless crystal, soluble in water and alcohol, slightly soluble in ether.
-Abbreviation: PATDA
-Molecular weight: about 155.15g/mol
-Density: about 1.25g/cm³
-Melting point: About 90-94 ° C (high uncertainty)
-Acidic: Tedizolid phosphate is an acidic substance.
Use:
- Tedizolid phosphate is mainly used as an acid catalyst in organic synthesis and catalytic reactions.
-It can be used as an intermediate in the synthesis of drugs, for example, Tedizolid phosphate can be used as a leuco dye intermediate preparation.
- Tedizolid phosphate can also be used to modify polymers and resins to adjust their properties.
Preparation Method:
The preparation method of Tedizolid phosphate usually includes the following steps:
1. Trimethylamine nitrate was synthesized from nitric acid.
2. React trimethylamine nitrate with phosphoric acid to generate Tedizolid phosphate.
3. Crystallization and purification process.
Safety Information:
- Tedizolid phosphate is stable at room temperature, but may decompose at high temperatures to produce toxic gases.
-It is a corrosive compound that can cause burning and irritation in contact with skin and eyes. Wear protective gloves, glasses and overalls when using.
-Avoid contact with strong oxidants and combustibles during use and storage to avoid dangerous reactions.
-When handling Tedizolid phosphate, care should be taken to follow relevant safe operating procedures, such as a well-ventilated operating environment and suitable personal protective equipment. In case of contact, rinse immediately with plenty of water and seek medical help.
Nature:
-Appearance: Tedizolid phosphate is a colorless crystal, soluble in water and alcohol, slightly soluble in ether.
-Abbreviation: PATDA
-Molecular weight: about 155.15g/mol
-Density: about 1.25g/cm³
-Melting point: About 90-94 ° C (high uncertainty)
-Acidic: Tedizolid phosphate is an acidic substance.
Use:
- Tedizolid phosphate is mainly used as an acid catalyst in organic synthesis and catalytic reactions.
-It can be used as an intermediate in the synthesis of drugs, for example, Tedizolid phosphate can be used as a leuco dye intermediate preparation.
- Tedizolid phosphate can also be used to modify polymers and resins to adjust their properties.
Preparation Method:
The preparation method of Tedizolid phosphate usually includes the following steps:
1. Trimethylamine nitrate was synthesized from nitric acid.
2. React trimethylamine nitrate with phosphoric acid to generate Tedizolid phosphate.
3. Crystallization and purification process.
Safety Information:
- Tedizolid phosphate is stable at room temperature, but may decompose at high temperatures to produce toxic gases.
-It is a corrosive compound that can cause burning and irritation in contact with skin and eyes. Wear protective gloves, glasses and overalls when using.
-Avoid contact with strong oxidants and combustibles during use and storage to avoid dangerous reactions.
-When handling Tedizolid phosphate, care should be taken to follow relevant safe operating procedures, such as a well-ventilated operating environment and suitable personal protective equipment. In case of contact, rinse immediately with plenty of water and seek medical help.
Last Update：2024-04-09 15:16:34
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