861214-33-7
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
CAS: 861214-33-7
Molecular Formula: C16H10FN3O2
861214-33-7 - Names and Identifiers
| Name | 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime |
| Synonyms | 5'-FIO -Fluoroindirubinoxime 5'-Fluoroindirubinoxime 5'-Fluoroindirubinoxime (5'-FIO) 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime 2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-5-fluoro-1,3-dihydro- |
| CAS | 861214-33-7 |
861214-33-7 - Physico-chemical Properties
| Molecular Formula | C16H10FN3O2 |
| Molar Mass | 295.27 |
| Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| In vitro study | 5'-Fluoroindirubinoxime (5’-FIO, compound 13) exhibits IC 50 values of 1.53 μM and 1.27 μM for VEGFR2 and Aurora A, respectively. 5'-Fluoroindirubinoxime (5’-FIO) exhibits IC 50 values of 12.2 μM, 2.1 μM, 3.4 μM and 5.1 μM in A549, SNU-638, HT-1080 and RK3E-ras cancer cells, respectively. 5'-Fluoroindirubinoxime (5’-FIO) induces the apoptosis in RK3E-ras cells. |
861214-33-7 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.39 ml | 16.949 ml | 33.898 ml |
| 5 mM | 0.678 ml | 3.39 ml | 6.78 ml |
| 10 mM | 0.339 ml | 1.695 ml | 3.39 ml |
| 5 mM | 0.068 ml | 0.339 ml | 0.678 ml |
Last Update：2024-01-02 23:10:35
861214-33-7 - Reference Information
| biological activity | 5 '-fluorobinrubbinoxime (compound 13) is a derivative of Indirubin (HY-N0117), which is an inhibitor of FLT3, its IC50 value is 15 nM. |
| Target | 15 nM (FLT3). |
| Animal Model: | Rat tumor model based RK3E-ras cells. |
| Dosage: | S.C.. |
| Administration: | 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6. |
| Result: | Effectively inhibited tumor growth. |
Last Update：2024-04-10 22:29:15
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CAS: 861214-33-7
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CAS: 861214-33-7
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