862539-91-1

862539-91-1 - Names and Identifiers

Name	4-Fluoro-2-methylbenzyl bromide
Synonyms	FR C1 D1E FR C1 D1E [WLN] -4-fluoro-2-methylbenzene 4-FLUORO-2-METHYLBENZYL BROMIDE 4-Fluoro-2-methylbenzyl bromide 2-Methyl-4-fluorobenzyl bromide 1-(Bromomethyl)-4-fluoro-2-methylbenzene Benzene, 1-(bromomethyl)-4-fluoro-2-methyl-
CAS	862539-91-1
InChI	InChI=1/C8H8BrF/c1-6-4-8(10)3-2-7(6)5-9/h2-4H,5H2,1H3

862539-91-1 - Physico-chemical Properties

Molecular Formula	C8H8BrF
Molar Mass	203.05
Density	1.456
Boling Point	221℃
Flash Point	91℃
Water Solubility	Insoluble in water.
Vapor Presure	0.16mmHg at 25°C
Storage Condition	2-8℃
Refractive Index	1.5495
MDL	MFCD03701059

862539-91-1 - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed
UN IDs	UN1760
Hazard Class	8
Packing Group	III

862539-91-1 - Introduction

4-Fluoro-2-methylbenzyl bromide is an organic compound with the chemical formula C8H8BrF. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: colorless liquid
-Boiling point: about 170-175 degrees Celsius
-Density: about 1.42 g/ml

Use:
- 4-Fluoro-2-methylbenzyl bromide can be used as intermediates in organic synthesis, such as in drug synthesis and pesticide synthesis.
-It can also be studied as a derivative of heterocyclic compounds.

Preparation Method:
The preparation method of 4-Fluoro-2-methylbenzyl bromide can be carried out by the following steps:
1. First, 2-methyl acetophenone is reacted with fluorocarbon alkyl tetrafluoromethanesulfonate to generate 2-methyl -4-bromo acetophenone.
2. Next, 2-methyl-4-bromoacetophenone was reacted with hydrogen bromide under basic conditions to obtain 4-bromo-2-methylacetophenone.
3. Finally, 4-bromo -2-methyl acetophenone is reacted with potassium fluoride to generate 4-fluoro -2-methyl acetophenone under alkaline conditions.
4. 4-fluoro-2-methylacetophenone is converted into 4-Fluoro-2-methylbenzyl bromide by a bromobenzylation reaction.

Safety Information:
- 4-Fluoro-2-methylbenzyl bromide is an irritant compound that may be harmful to the skin, eyes and respiratory system. Appropriate protective measures should be taken during handling, such as wearing protective gloves and goggles to ensure good ventilation.
-It should be stored in a sealed container, away from fire and oxidizing agents.
-Follow the proper handling and storage of chemicals and refer to the relevant safety information forms.

Last Update：2024-04-09 21:01:54