864830-16-0
2-FLUORO-4-METHYL-5-BROMOPYRIDINE
CAS: 864830-16-0
Molecular Formula: C6H5BrFN
864830-16-0 - Names and Identifiers
| Name | 2-FLUORO-4-METHYL-5-BROMOPYRIDINE |
| Synonyms | 5-Bromo-2-fluoro-4-picoline 5-Bromo-2-fluoro-4-methylpyridine 2-FLUORO-4-METHYL-5-BROMOPYRIDINE 5-Bromo-2-fluoro-4-methyl-pyridine 5-Bromo-2-Fluoro-4-Methyl-Pyridine Pyridine,5-bromo-2-fluoro-4-methyl- Pyridine, 5-bromo-2-fluoro-4-methyl- |
| CAS | 864830-16-0 |
| InChI | InChI=1/C6H5BrFN/c1-4-2-6(8)9-3-5(4)7/h2-3H,1H3 |
864830-16-0 - Physico-chemical Properties
| Molecular Formula | C6H5BrFN |
| Molar Mass | 190.01 |
| Density | 1.592±0.06 g/cm3(Predicted) |
| Boling Point | 208.9±35.0 °C(Predicted) |
| Flash Point | 80.2°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 0.301mmHg at 25°C |
| Appearance | Liquid |
| Color | Colorless to pale yellow |
| pKa | -2.13±0.18(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.5300 |
864830-16-0 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| Hazard Class | IRRITANT |
864830-16-0 - Introduction
It is an organic compound with the molecular formula C≡H∞BrFN, which has a fluorine atom, a methyl group and a bromine atom substituted on the pyridine ring.
Nature:
is a solid, toxic and irritating. It is soluble in organic solvents such as ethanol and dimethylformamide at room temperature, and can hydrogen bond with some hydrogen bond acceptors (e. g., alcohols).
Use:
It is often used as a starting material or intermediate in organic synthesis reactions. It can be used in the preparation of pharmaceuticals, pesticides and other organic compounds. Its wide range of applications include pharmaceutical research, chemical synthesis and materials science.
Preparation Method:
The preparation method of fluorination can be achieved by benzyl bromination and fluorination. First, a benzyl compound (4-methylpyridine) is reacted with benzylidene bromide to produce a bromobenzyl compound (2-bromo-4-methylpyridine). This compound is then reacted with hydrofluoric acid to produce the corresponding fluorinated product (phosphonium).
Safety Information:
is toxic, should take appropriate protective measures. Avoid contact with skin, eyes and respiratory tract during operation. Should be used in a well-ventilated place, and wear appropriate protective glasses, gloves and masks. Store away from fire and oxidizing agents, and avoid reaction with other chemicals. If exposed or inhaled, seek medical advice immediately.
Nature:
is a solid, toxic and irritating. It is soluble in organic solvents such as ethanol and dimethylformamide at room temperature, and can hydrogen bond with some hydrogen bond acceptors (e. g., alcohols).
Use:
It is often used as a starting material or intermediate in organic synthesis reactions. It can be used in the preparation of pharmaceuticals, pesticides and other organic compounds. Its wide range of applications include pharmaceutical research, chemical synthesis and materials science.
Preparation Method:
The preparation method of fluorination can be achieved by benzyl bromination and fluorination. First, a benzyl compound (4-methylpyridine) is reacted with benzylidene bromide to produce a bromobenzyl compound (2-bromo-4-methylpyridine). This compound is then reacted with hydrofluoric acid to produce the corresponding fluorinated product (phosphonium).
Safety Information:
is toxic, should take appropriate protective measures. Avoid contact with skin, eyes and respiratory tract during operation. Should be used in a well-ventilated place, and wear appropriate protective glasses, gloves and masks. Store away from fire and oxidizing agents, and avoid reaction with other chemicals. If exposed or inhaled, seek medical advice immediately.
Last Update：2024-04-09 21:01:54
