870777-33-6 - Names and Identifiers
870777-33-6 - Physico-chemical Properties
Molecular Formula | C8H9BO3
|
Molar Mass | 163.97 |
Density | 1.2g/cm3 |
Boling Point | 370.9°C at 760 mmHg |
Flash Point | 178.1°C |
Vapor Presure | 3.72E-06mmHg at 25°C |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.54 |
870777-33-6 - Risk and Safety
Safety Description | S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
|
WGK Germany | 3 |
870777-33-6 - Introduction
(3-formyl-5-methylphenyl)boronic acid, chemical formula C9H9BO3, is an organic boronic acid compound. The following is a description of some of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: White crystalline solid
-Solubility: Soluble in organic solvents such as ethanol, dimethylformamide (DMF), slightly soluble in water
-Melting point: approximately 120°C-123°C
Use:
- (3-formyl-5-methylphenyl)boronic acid is commonly used as a reagent and catalyst in organic synthesis. It can be used to construct aromatic aldehyde, carboxylic acid and amide compounds.
-Because of its strong nucleophilicity and good reactivity, it can also be used in metal coordination chemistry, organic electrochemistry and other fields.
Preparation Method:
One commonly used method is by reacting benzaldehyde with a borate ester of p-tolylboronic acid (also known as a borate ester compound) under alkaline conditions. The specific preparation method is as follows:
1. In a cooling device with magnetic stirring, benzaldehyde and the borate ester of p-tolylboronic acid are mixed in a chemical equivalent manner.
2. Methanol, an alkali (such as sodium hydroxide) and a solvent (such as ethanol) are slowly added dropwise thereto to keep the reaction solution alkaline.
3. Continue to stir the reaction solution and react at room temperature for a certain time (usually several hours).
4. After the reaction, acidification treatment is carried out with acid, and the product is precipitated in water and organic solvent.
5. Filtration, washing and drying are carried out to obtain (3-formyl-5-methylphenyl)boronic acid.
Safety Information:
For specific safety information about (3-formyl-5-methylphenyl)boronic acid, please refer to the safety data sheet (SDS) of the compound or related literature. In handling and use, should follow the appropriate laboratory safety procedures, and strictly control the risk of contact with the eyes, skin and respiratory tract.
Last Update:2024-04-10 22:29:15