871224-64-5

871224-64-5 - Names and Identifiers

Name	(2R)-[6,7-Dimethoxy-1(S)-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,4-tetrahydroisoquinolin-2-yl]-N-methyl-2-phenylacetamide
Synonyms	CS-942 ACT078573 ACT-078573 Almorexant ACT 078573 Almorexant HCI ACT078573 HYDROCHLORIDE ACT078573 hydrochloride ACT-078573 HYDROCHLORIDE ACT 078573 HYDROCHLORIDE AlMorexant (hydrochloride) Almorexant HCl (Act-078573) (R)-2-((R)-6,7-diMethoxy-1-(4-(trifluoroMethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-Methyl-2-phenylacetaMide (R)-2-((R)-6,7-Dimethoxy-1-(4-(Trifluoromethyl)Phenethyl)-3,4-Dihydroisoquinolin-2(1H)-Yl)-N-Methyl-2-Phenylacetamide (2R)-[6,7-Dimethoxy-1(S)-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,4-tetrahydroisoquinolin-2-yl]-N-methyl-2-phenylacetamide (R)-2-((S)-1-(4-(trifluoromethyl)phenethyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide hydrochloride (alphaR,1S)-3,4-Dihydro-6,7-dimethoxy-N-methyl-alpha-phenyl-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-2(1H)-isoquinolineacetamide monohydrochloride
CAS	871224-64-5 913358-93-7

871224-64-5 - Physico-chemical Properties

Molecular Formula	C29H31F3N2O3
Molar Mass	512.5632496
Melting Point	196-200°C
Solubility	Chloroform (Slightly), Methanol (Slightly)
Appearance	Solid
Color	White
Storage Condition	-20°C Freezer
In vitro study	Almorexant inhibits 10 nM Human orexin-A-induced intracellular Ca
In vivo study	Almorexant (300 mg/kg, P. O.) decreased alertness and increased electrophysiologic parameters in male Wistar rats during non-REM and REM sleep periods. In dogs, Almorexant (100 mg/kg, oral) causes lethargy and increases surrogate markers of REM sleep. Almorexant induces potent antidepressant-like effects and recovery of stress-related hypothalamic deficits independent of neurological effects. In addition, Almorexant was also able to reduce ethanol self-administration in a high-drinking rodent model.

871224-64-5 - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	1.951 ml	9.755 ml	19.51 ml
5 mM	0.39 ml	1.951 ml	3.902 ml
10 mM	0.195 ml	0.975 ml	1.951 ml
5 mM	0.039 ml	0.195 ml	0.39 ml

Last Update：2024-01-02 23:10:35

871224-64-5 - Introduction

(2R)-[6,7-dimethoxy-1 (S)-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,-N-methyl-2-phenylacetamide is an organic compound with the chemical formula C14H18O4. It is a brown powder that is soluble in organic solvents at room temperature.

(2R)-[6,7-dimethoxy-1 (S)-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,-N-methyl-2-phenylacetamide are mainly used in the preparation of synthetic dyes and synthetic materials. It can be used as a dye intermediate for the preparation of various organic dyes, such as blue dyes, red dyes, etc. In addition,(2R)-[6,7-dimethoxy-1 (S)-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,-N-methyl-2-phenylacetamide can also be used to synthesize polymers, such as polyamide, polyester, etc., for the preparation of textiles, plastics and coatings.

Preparation of (2R)-[6,7-dimethoxy-1 (S)-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,]-The N-methyl-2-phenylacetamide method is generally obtained by esterification of benzoic acid and succinic acid. The specific step is to dissolve benzoic acid and succinic acid under acidic conditions, add esterifying agent and catalyst for heating reaction, and generate (2R)-[6,7-dimethoxy-1 (S)-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,]-N-methyl-2-phenylacetamide.

When using (2R)-[6,7-dimethoxy-1 (S)-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,]-Some safety precautions need to be paid attention to when N-methyl-2-phenylacetamide. (2R)-[6,7-dimethoxy-1 (S)-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,]-N-methyl-2-phenylacetamide may be irritating to the skin and eyes, so it is necessary to wear protective gloves, protective glasses, etc. during operation. At the same time to avoid inhalation of its dust, should be in a well-ventilated place to operate. If accidental exposure to (2R)-[6,7-dimethoxy-1 (S)-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,]-N-methyl-2-phenylacetamide, the affected area should be promptly flushed with water and medical help should be sought.

Last Update：2024-04-10 22:29:15