87190-79-2
AzddMeC
CAS: 87190-79-2
Molecular Formula: C10H14N6O3
87190-79-2 - Names and Identifiers
| Name | AzddMeC |
| Synonyms | CS-92 AzddMeC Az-Dcme Azidodideoxymethylcytidine 3'-azido-2',3'-dideoxy-5-methylcytidine 3'-Azido-2',3'-dideoxy-4-deoxo-4-imino-5-methyluridine |
| CAS | 87190-79-2 |
87190-79-2 - Physico-chemical Properties
| Molecular Formula | C10H14N6O3 |
| Molar Mass | 266.26 |
| Storage Condition | -20°C，密封，干燥 |
| In vitro study | AzddMeC (CS-92) is also effective against HIV-2 in lymphocytes. The replication of Friend murine virus is only weakly inhibited, and no effect is observed against HSV type 1 and type 2 and coxsackievirus B4. The interaction of the 5'-triphosphate of AzddMeC with HIV-1 reverse transcriptase indicated competitive inhibition (the inhibition constant, Kis, is 9.3 nM). |
| In vivo study | The pharmacokinetics of AzddMeC are characterized following intravenous and oral administration of 60 mg/kg of the compound to male rhesus monkeys. 3'-azido-3'-deoxythymidine (AZT) is a major metabolite of AzddMeC in monkeys. AzddMeC concentrations in serum declined rapidly in a biexponential fashion with the terminal half-life ranging from 0.5 to 1.3 hr. Renal excretion of unchanged nucleoside and metabolic deamination yielding AZT are the primary routes of AzddMeC clearance. The oral bioavailability is 26%. |
87190-79-2 - Reference Information
| biological activity | AzddMeC (CS-92) is an antiviral nucleoside analog that is also a potent, selective, inhibitor of HIV-1 reverse transcriptase and HIV-1 replication with oral activity. The EC50 values of AzddMeC were 9 nM and 6 nM in HIV-1 infected human PBM cells and HIV-1 infected human macrophages, respectively. |
Last Update：2024-04-10 22:29:15
