Name | NVP-BGJ398 |
Synonyms | BGJ 398 NVP-BGJ398 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea |
CAS | 872511-34-7 |
Molecular Formula | C26H31Cl2N7O3 |
Molar Mass | 560.48 |
Density | 1.354 |
Melting Point | >211°C (dec.) |
Boling Point | 747.9±60.0 °C(Predicted) |
Appearance | Shape White solid, color White |
pKa | 11.02±0.70(Predicted) |
Storage Condition | -20°C |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
Physical and Chemical Properties | Bioactive BGJ398 (NVP-BGJ398) is an effective and selective FGFR inhibitor, acting on FGFR1/2/3,IC50 is 0.9 nM/1.4 nM/1 nM, acting on FGFR is more than 40 times more selective than acting on FGFR4 and VEGFR2, and has almost no inhibitory activity on Abl, Fyn, Kit, Lck, Lyn and Yes. |
Use | Uses BGJ 398 is a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinases. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.784 ml | 8.921 ml | 17.842 ml |
5 mM | 0.357 ml | 1.784 ml | 3.568 ml |
10 mM | 0.178 ml | 0.892 ml | 1.784 ml |
5 mM | 0.036 ml | 0.178 ml | 0.357 ml |