876310-60-0

Name	2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE
Synonyms	RD9 RF 9 RF9 trifluoroacetate salt 1-Adamantanecarbonyl-Arg-Phe-NH2 2-Adamantanecarbonyl-Arg-Phe-NH2 2-ADAMANTANECARBONYL-ARG-PHE-NH2 2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE 1-Adamantanecarbonyl-Arg-Phe-NH2 trifluoroacetate salt L-Phenylalaninamide, N2-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-L-arginyl-
CAS	876310-60-0

Molecular Formula	C26H38N6O3
Molar Mass	482.62
Density	1.42±0.1 g/cm3(Predicted)
Solubility	H2O: soluble20mg/mL
pKa	14.53±0.20(Predicted)
Storage Condition	Store at -20°C
In vitro study	RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells.
In vivo study	RF9 (0.1 mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance. RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9. Animal Model: Rats. Dosage: 0.1 mg/kg. Administration: S.C. 30 min before 0.3 mg/kg heroin or saline on basal nociceptive threshold in rats. Result: Opposed to delaye heroin-induced hyperalgesia and associated tolerance.

WGK Germany

Last Update：2024-01-02 23:10:35

biological activity	RF9 is an effective and selective neuropeptide FF receptor (Neuropeptide FF receptor) antagonist, The Ki values for hNPFF1R and hNPFF2R are 58 and 7 nM respectively.
target	hNPFF1R 58 nM (Ki) hNPFF2R 75 nM (Ki)
in vitro study	RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells.
in vivo study	RF9 (0.1 mg/kg, S. c. ) with hero coadministration prevents hero-induced delayed hyperalgesia and tolerance. RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9. Animal Model: Rats. Dosage: 0.1 mg/kg. Administration: s.C. 30 min before 0.3 mg/kg nociceptive threshold in rat. Result: Opposed to delaye hero-induced hyperalgesia and associated tolerance.
Animal Model:	Rats.
Dosage:	0.1 mg/kg.
Administration:	S.C. 30 min before 0.3 mg/kg heroin or saline on basal nociceptive threshold in rats.
Result:	Opposed to delaye heroin-induced hyperalgesia and associated tolerance.

Last Update：2024-04-09 21:01:54

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