877950-01-1
LtaS-IN-1
CAS: 877950-01-1
Molecular Formula: C24H17N3O5
877950-01-1 - Names and Identifiers
877950-01-1 - Physico-chemical Properties
| Molecular Formula | C24H17N3O5 |
| Molar Mass | 427.41 |
| Density | 1.400±0.06 g/cm3(Predicted) |
| pKa | 9.67±0.70(Predicted) |
| Storage Condition | 2-8°C，干燥，密封 |
| In vitro study | LtaS-IN-1 (0-100 μM) inhibits strain E745 growth as a concentration-dependent manner. At the concentration 10 μM leads to an 60% reduction in the final OD600 for this strain. Meanwhile, LtaS-IN-1 does not affect E. faecium growth in control group. LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 inhibits strain E1630 and E1590 with the MIC values of 0.5μg/mL. LtaS-IN-1 (20 μM) combines with either ampicillin (20 μg/mL), gentamicin (10 μg/mL), linezolid (5 μg/mL), daptomycin (10 μg/mL+50 μg/mL calcium chloride) or vancomycin (20 μg/mL) can inhibit strains E7128 and E7130 growth by 97-100%, while LtaS-IN-1 alone only gives 73% (strain E7128) and 8% (strain E7130) of growth inhibition, respectively. |
877950-01-1 - Reference Information
| biological activity | LtaS-IN-1 (compound 1771) is an efficient small molecule lipoteichoic acid (LTA) inhibitor, which can inhibit the synthesis of lipoteichoic acid (LTA) in multidrug-resistant (MDR) Escherichia coli and change the morphology of cell wall. LtaS-IN-1 MIC values for inhibiting the growth of enterococci alone ranged from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combined with antibiotics can almost completely inhibit the growth of multi-drug resistant Escherichia coli. |
| target | MIC: 0.5 μg/mL (strain E1630); 0.5 μg/mL (strain E1590) |
| in vitro study | LtaS-IN-1 (0-100μM) inhibits strain E745 growth as a concentration-dependent banner. At the concentration 10 μM leader to an 60% reduction in the final OD600 for this strain. Meanwhile, ltaS-IN-1 does not affect e. faecium growth in control group. LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 inhibits strain E1630 and E1590 with the MIC values of 0.5 μg/mL. LtaS-IN-1 (20 μ M) combines with even ampicillin (20 μ g/mL), gentamicin (10 μ g/mL), linezolid (5 μg/mL), daptomycin (10 μg/mL +50 μg/mL calcium chloride) or vancomycin (20 μg/mL) can inhibit strains E7128 and E7130 growth by 97-100%, while LtaS-IN-1 only gives 73% (strain E7128) and 8% (strain E7130) of growth inhibition, respectively. |
Last Update：2024-04-10 22:29:15
