877997-98-3
Benzoic acid, 2-hydroxy-4,5-dimethoxy-, phenyl ester
CAS: 877997-98-3
Molecular Formula: C15H14O5
877997-98-3 - Names and Identifiers
877997-98-3 - Physico-chemical Properties
| Molecular Formula | C15H14O5 |
| Molar Mass | 274.27 |
| Density | 1.250±0.06 g/cm3(Predicted) |
| Boling Point | 431.2±45.0 °C(Predicted) |
| pKa | 8.83±0.23(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
877997-98-3 - Reference Information
| Application | phenyl 2-hydroxy-4, 5-dimethoxybenzoate is an important intermediate for the synthesis of 2-aminothiazole compounds. 2-aminothiazole compounds are an important class of heterocyclic compounds in organic pharmaceutical chemistry, which have a wide range of biological activity, can be used as local anesthetics, with anticonvulsant, antiviral, antibacterial and insecticidal effects. |
| preparation | phenyl 2-hydroxy-4, 5-dimethoxybenzoate was prepared as follows: reaction system under the protection of nitrogen, to the reactor was added toluene solvent 170g, triphenyl phosphite (compound 2)266g(0.86mol), 2-hydroxy-4, 5-dimethoxybenzoic acid (compound 1)170g(0.86mol) and 4.5 of concentrated sulfuric acid (98wt%), and heated to reflux (110 ° C.) for 3 hours. After the completion of the reaction, the temperature was lowered to 20 ℃, and 566g of methanol was added dropwise to the reaction system, stirred for 30min, then water was added dropwise for 283G, stirred for 30min, filtered and washed with water to obtain crude 2-hydroxy-4, phenyl 5-dimethoxybenzoate 230g, the crude product was washed with ethanol and then dried to obtain G of phenyl 2-hydroxy-4, 5-dimethoxybenzoate (yield 86.3%). |
Last Update：2024-04-09 15:16:53
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