87862-25-7

87862-25-7 - Names and Identifiers

Name	3-IODOBENZYL-GUANIDINE HEMISULFATE
Synonyms	M-IBG MIBG hemisulfate MIBG HEMISULFATE SALT IOBENGUANE HEMISULFATE m-iodobenzylguanidine sulfate 3-IODOBENZYL-GUANIDINE HEMISULFATE meta-Iodobenzylguanidine hemisulfate M-IODOBENZYLGUANIDINE HEMISULFATE SALT
CAS	87862-25-7

87862-25-7 - Physico-chemical Properties

Molecular Formula	C16H22I2N6O4S
Molar Mass	648.26
Storage Condition	2-8°C
In vitro study	Iobenguane sulfate (MIBG sulfate) (2-20 μg/ml; 72 hours) inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines. Iobenguane sulfate (MIBG sulfate) is a potent affector of endogenous mono(ADP-ribosyl) transferases of turkey and human erythrocyte membranes, exerting its effect in the μM concentration range. Cell Proliferation Assay Cell Line: 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, CHP212 cells Concentration: 2, 20μg/ml Incubation Time: 72 hours Result: Inhibits 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, and CHP212 cells growth.
In vivo study	Iobenguane sulfate (MIBG hemisulfate) (20 mg/kg; i.p.; daily on days 3-6) shows antitumor activity. The survival of male strain AF mice inoculates with N1E115 neuroblastoma and treats according to NIH protocols for new drug testing with 9 daily injections of Iobenguane sulfate (40 mg/kg), Marking prolongation of sugvival but no cures were observed. Iobenguane sulfate testes for its toxicity on male strain AF (N1Ell5) mice with 5 daily injections. At 50 mg/kg body weight, all animals died after 1-4 doses and 4/16 animals died on a schedule of 44 mg/kg. Animal Model: DBA/2 (L1210)) mice Dosage: i.p.; daily on days 3-6 Administration: 20 mg/kg Result: Considerable prolongation of survival and some cures were obtained.

87862-25-7 - Risk and Safety

WGK Germany

87862-25-7 - Introduction

3-IODOBENZYL-GUANIDINE HEMISULFATE is an organic compound with the chemical formula C8H10IN5 · 0.5H2SO4. The following is a description of its nature, use, preparation and safety information:

Nature:
3-IODOBENZYL-GUANIDINE HEMISULFATE is a crystalline solid, soluble in water. Its molecule contains a benzene ring and a furan ring, as well as a guanidine group and an iodine atom. It has a strong alkaline.

Use:
3-IODOBENZYL-GUANIDINE HEMISULFATE is mainly used as an intermediate in organic synthesis. It can be used to synthesize various compounds such as drugs, pesticides and dyes. In addition, it can also be used as an electrochemical catalyst.

Preparation Method:
3-IODOBENZYL-GUANIDINE HEMISULFATE can be prepared by reacting 3-iodobenzylguanidine with sulfuric acid. The specific step may be reacting 3-iodobenzylguanidine with sulfuric acid under alkaline conditions to generate 3-IODOBENZYL-GUANIDINE HEMISULFATE.

Safety Information:
There is less safety information about 3-IODOBENZYL-GUANIDINE HEMISULFATE. As a chemical, it may bring certain harm to human body and environment. Use and store chemicals in safe practice and avoid direct contact with skin, eyes and respiratory tract. If you come into contact with this substance, rinse immediately with plenty of water and seek medical attention. Appropriate personal protective equipment such as laboratory gloves, goggles and protective clothing should be used when handling the substance.

Last Update：2024-04-09 21:54:55