879551-04-9
(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one
CAS: 879551-04-9
Molecular Formula: C6H9FO4
879551-04-9 - Names and Identifiers
879551-04-9 - Physico-chemical Properties
| Molecular Formula | C6H9FO4 |
| Molar Mass | 164.13 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Melting Point | 142-143℃ (ethyl acetate heptane ) |
| Boling Point | 352.7±42.0 °C(Predicted) |
| pKa | 11.46±0.60(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Use | Intermediate |
879551-04-9 - Reference Information
| function | nucleoside drugs are an important class of antiviral drugs. Such drugs in the human body, after phosphorylation into nucleoside triphosphates, can inhibit Virus of the DNA reverse transcriptase activity, while nucleoside triphosphates also by penetrating Virus of the DNA, the synthesis of DNA was inhibited by Virus, and the replication was effectively inhibited by Virus to exert effective anti-Virus activity. |
| preparation | trans-5-hydroxy-1, chlorination or acylation of 3-oxosulfate heterocyclic pentane -2-carboxylic acid-L-menthol Ester, followed by a coupling reaction with cytosine and 5-fluorocytosine or with organo-Silicon protected cytosine and 5-fluorocytosine, however, in the chlorination or acylation process, there is a higher requirement for maintaining the chiral structure, and at the same time, the process flow is extended, the process cost is increased, and the yield of the final product is reduced. |
Last Update：2024-04-09 21:11:58
Supplier List
Spot supply
Product Name: Sofosbuvir Impurity 122 Visit Supplier Webpage Request for quotationCAS: 879551-04-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one Visit Supplier Webpage Request for quotation
CAS: 879551-04-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 879551-04-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Sofosbuvir Impurity 122 Visit Supplier Webpage Request for quotationCAS: 879551-04-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one Visit Supplier Webpage Request for quotation
CAS: 879551-04-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 879551-04-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History