88122-52-5
Notoginsenoside Fc
CAS: 88122-52-5
Molecular Formula: C58H98O26
88122-52-5 - Names and Identifiers
88122-52-5 - Physico-chemical Properties
| Molecular Formula | C58H98O26 |
| Molar Mass | 1211.38 |
| Density | 1.47±0.1 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 219-223°C |
| Specific Rotation(α) | (c, 0.67 in H2O)-1.4 |
| Solubility | Soluble in water, methanol, ethanol, soluble in hot water, insoluble in ether, n-butyl imitation and benzene. |
| Appearance | White crystal |
| pKa | 12.84±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD23379929 |
| Physical and Chemical Properties | Soluble in methanol, ethanol, DMSO and other organic solvents, derived from notoginseng. |
| Use | Used for content determination/identification/pharmacological experiments, etc. Panax notoginsenoside Fc is a protopanaxadiol type (PPD type) saponin isolated from Panax notoginseng plants, which has good anti-platelet aggregation effect. |
| In vitro study | Notoginsenoside Fc (20 μM; for 24 h) markedly upregulates the expression of LC3B and Beclin 1 and downregulated that of p62 in RAOECs. |
| In vivo study | Notoginsenoside Fc (3.5 mg/kg/day) accelerates reendothelialization and alleviates excessive neointimal formation following carotid artery injury in diabetic Sprague-Dawley rats (200±20 g) in vivo. |
88122-52-5 - Reference
| Reference Show more | 1. Liu Wenbin, Wang Jianbo, Feng Li Shuai, Liu Jing Jing. Mechanism of notoginsenoside FC inhibiting inflammation and apoptosis of RAW264.7 cells through MAPK/NF-κB pathway [J]. Journal of Shanghai University of Traditional Chinese Medicine, 2020,34(05):64-71. 2. Jingjing Liu, Chunyu Jiang, Xu Ma, Lishuai Feng, Jianbo Wang, "noginsenfavor Fc accelerated Cell automation. 2019, Article ID 9696 3. [IF = 3.33] Jingjing Liu et al."Notoginsenoside Fc attenuates high glucose-induced vascular endothelial cell injury via upregulation of PPAR-γ in diabetic Sprague-Dawley rats."Vasc Pharmacol. 2018 Oct;109:27 4. [IF=3.361] Yuhao Zhang et al."An integrated approach for structural characterization of Gui Ling Ji by traveling wave ion mobility mass spectrometry and molecular network."Rsc Adv. 2021 Apr;11(26):15546-15556 5. [IF=3.04] Liu Jingjing et al."Notoginsenoside Fc Accelerates Reendothelialization following Vascular Injury in Diabetic Rats by Promoting Endothelial Cell Autophagy."J Diabetes Res. 2019;2019:9696521 |
88122-52-5 - Introduction
Panax notoginseng saponin FC is a natural active ingredient extracted from the roots of Panax notoginseng. Panax Notoginseng (scientific name: Panax Notoginseng) is a common herbaceous plant that mainly grows in Yunnan, Sichuan, Guangxi and other regions of China.
Sanqi saponin FC is a variant of Sanqi saponin, which has various biological activities such as anti-inflammatory, antioxidant, antibacterial, and anti-tumor effects. Research has shown that Panax notoginseng saponin FC can enhance the body's immune function, regulate blood circulation, reduce blood lipids, and inhibit platelet aggregation.
Sanqi saponin FC also has antioxidant effects, which can eliminate free radicals in the body and reduce the damage of oxidative stress to the body.
In terms of preparation, Panax notoginseng saponin FC is generally extracted and purified from Panax notoginseng roots and stems through methods such as water extraction, alcohol precipitation, and silica gel column chromatography. During the extraction process, attention should be paid to controlling the temperature and pH value to avoid damage to the active ingredients.
Safety information, attention should be paid to the possibility of allergic reactions in individuals with allergies. When applying, it should be used according to the product manual and comply with relevant safety operating regulations. When allergies or other discomfort symptoms occur during use, stop using immediately and seek advice from a professional doctor.
Last Update：2024-04-09 19:55:45
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Spot supply
Product Name: Notoginsenoside Fc Visit Supplier Webpage Request for quotationCAS: 88122-52-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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