882256-55-5
iGOT1-01
CAS: 882256-55-5
Molecular Formula: C19H20N4O
882256-55-5 - Names and Identifiers
882256-55-5 - Physico-chemical Properties
| Molecular Formula | C19H20N4O |
| Molar Mass | 320.39 |
| Density | 1.314±0.06 g/cm3(Predicted) |
| Boling Point | 620.8±55.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| pKa | 13.94±0.70(Predicted) |
| Storage Condition | -20℃ |
| Use | iGOT1-01 is a potent inhibitor of aspartate aminotransferase 1 (glutamate oxaloacetate aminotransferase 1;GOT1) with an IC50 of 85 μM in the MDH-coupled GOT1 enzymatic assay. iGOT1-01 has anti-cancer activity. |
882256-55-5 - Reference
| Reference Show more | 1: Holt MC, Assar Z, Beheshti Zavareh R, Lin L, Anglin J, Mashadova O, Haldar D, Mullarky E, Kremer DM, Cantley LC, Kimmelman AC, Stein AJ, Lairson LL, Lyssiotis CA. Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry. 2018 Nov 27;57(47):6604-6614. doi: 10.1021/acs.biochem.8b00914. Epub 2018 Nov 12. PubMed PMID: 30365304; PubMed Central PMCID: PMC6487875. |
882256-55-5 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.121 ml | 15.606 ml | 31.212 ml |
| 5 mM | 0.624 ml | 3.121 ml | 6.242 ml |
| 10 mM | 0.312 ml | 1.561 ml | 3.121 ml |
| 5 mM | 0.062 ml | 0.312 ml | 0.624 ml |
Last Update：2024-01-02 23:10:35
