Name | 2-bromo-3-fluoro-4-methyl-pyridine |
Synonyms | LogP 2-Bromo-3-fluoro-4-picoline 2-BROMO-3-FLUORO-4-PICOLINE 2-bromo-3-fluoro-4-methylpyridine 2-bromo-3-fluoro-4-methyl-pyridine pyridine, 2-bromo-3-fluoro-4-methyl- Pyridine, 2-bromo-3-fluoro-4-methyl- |
CAS | 884494-37-5 |
InChI | InChI=1/C6H5BrFN/c1-4-2-3-9-6(7)5(4)8/h2-3H,1H3 |
Molecular Formula | C6H5BrFN |
Molar Mass | 190.01 |
Density | 1.592 |
Boling Point | 204℃ |
Flash Point | 77℃ |
Vapor Presure | 0.386mmHg at 25°C |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.529 |
Hazard Class | IRRITANT |
Overview | 2-bromo-3-fluoro-4-methylpyridine is a fluorine-containing pyridine compound. Pyridine derivatives are an important class of pharmaceutical intermediates, which can be used as raw materials for the synthesis of steroids, sulfonamides, resistance amines and Spiro amides. As an important pyridine derivative, fluorine-containing pyridine compounds are widely used in the synthesis of organic synthesis and drug intermediates. Because the atomic radii of fluorine atoms and hydrogen atoms are quite close, when the hydrogen atoms in the molecule are replaced by fluorine atoms, it will not cause significant changes in the three-dimensional configuration of the molecule. However, because the fluorine atom has a strong ability to absorb electrons, the electronic properties of the original molecule are often greatly changed, so that the fluorine-containing pyridine has good stability and large dielectric anisotropy, therefore, in recent years, fluorine-containing pyridine compounds have a very important role in medicine, especially in the synthesis of anticancer drugs and drugs for the treatment of cardiovascular and cerebrovascular diseases. |