88578-90-9
2-chloro-4-fluorobenzamide
CAS: 88578-90-9
Molecular Formula: C7H5ClFNO
88578-90-9 - Names and Identifiers
| Name | 2-chloro-4-fluorobenzamide |
| Synonyms | ZVR BG DF 2-CHLORO-4-FLUOROBENZAMIDE 2-chloro-4-fluorobenzamide Benzamide, 2-chloro-4-fluoro- |
| CAS | 88578-90-9 |
| InChI | InChI=1/C7H5ClFNO/c8-6-3-4(9)1-2-5(6)7(10)11/h1-3H,(H2,10,11) |
88578-90-9 - Physico-chemical Properties
| Molecular Formula | C7H5ClFNO |
| Molar Mass | 173.57 |
| Density | 1.396g/cm3 |
| Melting Point | 152 °C |
| Boling Point | 238.8°C at 760 mmHg |
| Flash Point | 98.2°C |
| Vapor Presure | 0.0417mmHg at 25°C |
| Storage Condition | Room Temprature |
| Refractive Index | 1.557 |
88578-90-9 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| Hazard Class | IRRITANT |
88578-90-9 - Introduction
2-chloro-4-fluorobenzamide, chemical formula C7H5ClFNO, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Colorless or light yellow crystal
-Solubility: better solubility in common organic solvents
-Melting point: approximately between 110-115 degrees Celsius
-relative molecular mass: 177.57g/mol
Use:
-2-chloroo-4-fluorobenzamide can be used as an intermediate in the synthesis of drugs, pesticides and dyes.
-It may have anti-inflammatory, anti-cancer and antibacterial activities in the pharmaceutical field, and can be used in the research and development of synthetic new drugs.
Preparation Method:
The preparation of 2-choro-4-fluorobenzamide can be carried out by the following steps:
1. Under appropriate conditions, benzoic acid and 2-chloro-4-fluoroaniline were acylated to obtain 2-chloro-4-fluorobenzoic acid.
2.2-chloro -4-fluorobenzoic acid is converted into 2-chloro -4-fluorobenzoyl chloride by decarboxylation reaction.
3. Finally, 2-chloro-4-fluorobenzoyl chloride is reacted with ammonia water or ammonia gas to obtain 2-chloro-4-fluorobenzamide.
Safety Information:
2-choro-4-fluorobenzamide is an organic compound that may be toxic. Appropriate safety precautions should be taken during use and handling, including wearing appropriate personal protective equipment (such as gloves, goggles, protective clothing, etc.).
-Avoid contact with skin, eyes and respiratory tract. In the case of accidental contact, immediately flush the affected area with plenty of water and seek medical help.
-During storage and transportation, the tightness of 2-chloro-4-fluorobenzamide should be maintained, and away from fire and oxidizing agents.
-Comply with laws and regulations and safe operating procedures to ensure the correct use and handling of the compound.
Nature:
-Appearance: Colorless or light yellow crystal
-Solubility: better solubility in common organic solvents
-Melting point: approximately between 110-115 degrees Celsius
-relative molecular mass: 177.57g/mol
Use:
-2-chloroo-4-fluorobenzamide can be used as an intermediate in the synthesis of drugs, pesticides and dyes.
-It may have anti-inflammatory, anti-cancer and antibacterial activities in the pharmaceutical field, and can be used in the research and development of synthetic new drugs.
Preparation Method:
The preparation of 2-choro-4-fluorobenzamide can be carried out by the following steps:
1. Under appropriate conditions, benzoic acid and 2-chloro-4-fluoroaniline were acylated to obtain 2-chloro-4-fluorobenzoic acid.
2.2-chloro -4-fluorobenzoic acid is converted into 2-chloro -4-fluorobenzoyl chloride by decarboxylation reaction.
3. Finally, 2-chloro-4-fluorobenzoyl chloride is reacted with ammonia water or ammonia gas to obtain 2-chloro-4-fluorobenzamide.
Safety Information:
2-choro-4-fluorobenzamide is an organic compound that may be toxic. Appropriate safety precautions should be taken during use and handling, including wearing appropriate personal protective equipment (such as gloves, goggles, protective clothing, etc.).
-Avoid contact with skin, eyes and respiratory tract. In the case of accidental contact, immediately flush the affected area with plenty of water and seek medical help.
-During storage and transportation, the tightness of 2-chloro-4-fluorobenzamide should be maintained, and away from fire and oxidizing agents.
-Comply with laws and regulations and safe operating procedures to ensure the correct use and handling of the compound.
Last Update：2024-04-09 21:00:56
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CAS: 88578-90-9
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Mobile: 18021002903
QQ: 3008007409
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CAS: 88578-90-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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