887686-02-4
OSS-128167
CAS: 887686-02-4
Molecular Formula: C19H14N2O6
887686-02-4 - Names and Identifiers
887686-02-4 - Physico-chemical Properties
| Molecular Formula | C19H14N2O6 |
| Molar Mass | 366.32 |
| Solubility | DMSO : 103.3 mg/mL (281.99 mM; Need ultrasonic and warming) |
| Appearance | Solid |
| Color | Red to Very Dark Brown |
| Storage Condition | 2-8°C |
| In vitro study | OSS-128167 has specificity for SIRT6, which is approximately 20-fold higher in IC50s for SIRT1 and SIRT2 than for sirt6. It is cell permeable and active in cultured cells. OSS-128167 increased H3K9 acetylation and GLUT-1 expression. |
| In vivo study | OSS_128167 (50 mg/kg; intraperitoneal injection; every 4 days; for 12 days; male HBV transgenic mice) treatment markedly suppresses the level of HBV DNA and 3.5-Kb RNA in HBV transgenic mice. Animal Model: Male HBV transgenic mice (6-8-week-old) Dosage: 50 mg/kg Administration: Intraperitoneal injection; every 4 days; for 12 days Result: The level of HBV DNA and 3.5-Kb RNA were markedly suppressed in HBV transgenic mice. |
887686-02-4 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.73 ml | 13.649 ml | 27.298 ml |
| 5 mM | 0.546 ml | 2.73 ml | 5.46 ml |
| 10 mM | 0.273 ml | 1.365 ml | 2.73 ml |
| 5 mM | 0.055 ml | 0.273 ml | 0.546 ml |
Last Update：2024-01-02 23:10:35
887686-02-4 - Introduction
OSS-128167 is a chemical with the chemical name N-(4-chloro-3-methylphenyl)-6-methyl -2-aminopyridin -3-amine. The following is a description of the nature, use, preparation and safety information of the OSS-128167:
Nature:
-Appearance: The OSS-128167 is a white crystalline solid.
-Solubility: Can be dissolved in some organic solvents, such as dimethyl sulfoxide and dichloromethane.
-Melting point: The melting point of the OSS-128167 is about 118-120 degrees Celsius.
Use:
- OSS-128167 is widely used as a pharmaceutical intermediate and can be used to synthesize a variety of pharmaceutical compounds.
-It has certain bactericidal activity, so it can also be used for pesticides.
Preparation Method:
-Although there are many ways to make OSS-128167, in actual production, sodium amide and 2-chlorine -6-methyl nicotinaldehyde are often used to participate in the reaction.
-The main step of this preparation method is to react the above two compounds to form OSS-128167.
Safety Information:
- OSS-128167 should be used with caution, it may be irritating to the skin, eyes and respiratory tract.
-Care should be taken when handling this compound, such as wearing protective gloves, glasses and masks.
-Avoid inhaling its dust or contacting its solution when using this compound.
-When storing and handling this compound, follow safe operating procedures and place it in a cool and dry place away from heat and flammable materials.
Nature:
-Appearance: The OSS-128167 is a white crystalline solid.
-Solubility: Can be dissolved in some organic solvents, such as dimethyl sulfoxide and dichloromethane.
-Melting point: The melting point of the OSS-128167 is about 118-120 degrees Celsius.
Use:
- OSS-128167 is widely used as a pharmaceutical intermediate and can be used to synthesize a variety of pharmaceutical compounds.
-It has certain bactericidal activity, so it can also be used for pesticides.
Preparation Method:
-Although there are many ways to make OSS-128167, in actual production, sodium amide and 2-chlorine -6-methyl nicotinaldehyde are often used to participate in the reaction.
-The main step of this preparation method is to react the above two compounds to form OSS-128167.
Safety Information:
- OSS-128167 should be used with caution, it may be irritating to the skin, eyes and respiratory tract.
-Care should be taken when handling this compound, such as wearing protective gloves, glasses and masks.
-Avoid inhaling its dust or contacting its solution when using this compound.
-When storing and handling this compound, follow safe operating procedures and place it in a cool and dry place away from heat and flammable materials.
Last Update：2024-04-09 20:49:11
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Spot supply
Product Name: OSS-128167 Visit Supplier Webpage Request for quotationCAS: 887686-02-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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