890-38-0
2'-Deoxyinosine
CAS: 890-38-0
Molecular Formula: C10H12N4O4
890-38-0 - Names and Identifiers
| Name | 2'-Deoxyinosine |
| Synonyms | Deoxyinosine 2'-Deoxyinosine Inosine, 2'-deoxy- 2'-Deoxyinosine(Di) DEOXYINOSINE, 2'-(RG) Didanosine EP Impurity C 1,9-Dihydro-9-(2'-deoxy-β-D-ribofuranosyl)-6H-purin-6-one 9-[(2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-9H-purin-6-ol 9-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol |
| CAS | 890-38-0 |
| EINECS | 212-964-1 |
| InChI | InChI=1/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1 |
890-38-0 - Physico-chemical Properties
| Molecular Formula | C10H12N4O4 |
| Molar Mass | 252.23 |
| Density | 1.3402 (rough estimate) |
| Melting Point | 250 °C |
| Boling Point | 395.4°C (rough estimate) |
| Specific Rotation(α) | 21 º (c=1, H2O 22 ºC) |
| Flash Point | 365.8°C |
| Water Solubility | 8.33g/L(25.02 ºC) |
| Solubility | , Soluble in organic solvents such as methanol, ethanol, DMSO, etc. |
| Vapor Presure | 1.72E-19mmHg at 25°C |
| Appearance | White powder |
| Color | White to Off-white |
| BRN | 33517 |
| pKa | 8.92±0.70(Predicted) |
| Storage Condition | -20°C |
| Refractive Index | -16 ° (C=1, H2O) |
| MDL | MFCD00005762 |
| Physical and Chemical Properties | White powder, soluble in methanol, ethanol, DMSO and other organic solvents. |
| In vitro study | In the absence of deoxycoformycin, 2’-deoxyadenosine is primarily deaminated to 2’-deoxyinosine and then converted into hypoxanthine. In the presence of the inhibitor, the deoxynucleoside, in addition to a phosphorylation process, undergoes phosphorolytic cleavage giving rise to adenine. The conversion of 2’-deoxyadenosine to adenine might represent a protective device, emerging when the activity of adenosine deaminase is reduced or inhibited. There is much evidence to indicate that the enzyme catalyzing this processs may be distinct from methylthioadenosine phosphorylase and S-adenosyl homocysteine hydrolase, which are the enzymes reported to be responsible for the formation of adenine from 28-deoxyadenosine in mammals. |
890-38-0 - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-23 |
| HS Code | 29349990 |
890-38-0 - Reference
| Reference Show more | 1. Xiao Hui-min, He Yue, ramena, etc. HPLC characteristic chromatogram and quantitative analysis of 10 components of earthworm capsule [J]. Northwest Pharmaceutical Journal, 2018, 033(005):569-574. 2. He Yue, Xiao Hui-min, Kang Xiao-Gang, et al. Study on radiosensitization of earthworm capsule and its principal components on S_(180) transplanted tumor in mice [J]. Northwest Pharmaceutical Journal, 2019. 3. [IF = 6.529] Yarigui Bao et al."Therapeutic effects of Chinese medicine Di-Long (Pheretima vulgaris) on rheumatoid arthritis." Biomed Pharmacother. 2022 Mar;147:112643 |
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CAS: 890-38-0
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Product Name: 2'-Deoxyinosine Request for quotationCAS: 890-38-0
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