890128-81-1
BFH772
CAS: 890128-81-1
Molecular Formula: C23H16F3N3O3
890128-81-1 - Names and Identifiers
890128-81-1 - Physico-chemical Properties
| Molecular Formula | C23H16F3N3O3 |
| Molar Mass | 439.39 |
| Density | 1.432±0.06 g/cm3(Predicted) |
| Boling Point | 541.2±50.0 °C(Predicted) |
| Solubility | DMSO: 7.75 mg/mL |
| pKa | 12.65±0.70(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | BFH772 effectively targets VEGFR2 with an IC50 of 3 nM. The effectiveness of FLK-1, FLT-1 and FLT-4 was 500 times lower than that of VEGFR2. In addition to VEGFR2, it can target B- RAF, RET and TIE-2, although they are more than 40-fold less effective than VEGFR2. BFH772 inhibits ligand-induced autophosphorylation of RET, PDGFR, and KIT kinases with an IC50 of 30-160 nM. |
| In vivo study | Daily oral administration of 3 mg/kg of BFH772 was effective in inhibiting melanoma growth (54-90% reduction for primary tumors; 71-96% reduction for metastases). |
890128-81-1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.276 ml | 11.379 ml | 22.759 ml |
| 5 mM | 0.455 ml | 2.276 ml | 4.552 ml |
| 10 mM | 0.228 ml | 1.138 ml | 2.276 ml |
| 5 mM | 0.046 ml | 0.228 ml | 0.455 ml |
Last Update：2024-01-02 23:10:35
890128-81-1 - Reference Information
| biological activity | BFH772 is a new, effective and orally available VEGFR2 inhibitor with IC50 of 3 nM. |
| target | TargetValue VEGFR2 (Cell-free say) 3 nM |
| Target | Value |
| VEGFR2 (Cell-free assay) | 3 nM |
| in vitro study | BFH772 effectively targets VEGFR2 with IC50 of 3 nM. However, the effectiveness of FLK-1, FLT-1 and FLT-4 is 500 times lower than that of VEGFR2. In addition to VEGFR2, it can also target B- RAF, RET and TIE-2, although its effectiveness is more than 40 times lower than VEGFR2. BFH772 inhibits ligand-induced autophosphorylation of RET, PDGFR, and KIT kinase with an IC50 of 30-160 nM. |
| in vivo study | oral administration of 3 mg/kg BFH772 per day can effectively inhibit the growth of melanoma (for primary tumors, reduce 54-90%; For metastatic tumors, reduce 71-96%). |
Last Update：2024-04-09 01:59:59
Supplier List
Spot supply
Product Name: BFH772 Visit Supplier Webpage Request for quotationCAS: 890128-81-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: BFH772 Visit Supplier Webpage Request for quotationCAS: 890128-81-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History