89889-52-1

89889-52-1 - Names and Identifiers

Name	BIOTIN-XX-NHS
Synonyms	BIOTIN-XX-NHS Biotin-AC5-AC5-OSU N-SUCCINIMIDYL N-6-(BIOTINYLAMINO)CAP 6-(BIOTINAMIDOCAPROYLAMIDO)CAPROIC ACID N-HYDROXYSU Biotinamidohexanoyl-6-aminohexanoic acid N-hydroxysuccinimide ester 6-[6-(Biotinylamino)hexanoylamino]hexanoicacidN-hydroxysuccinimideester 6-((+)-Biotinamidohexanoylamino)hexanoic acid N-hydroxysuccinimide ester 5-[5-(N-SUCCINIMIDYLOXYCARBONYL)PENTYLAMIDO]HEXYL D-BIOTINAMIDE (BIOTIN-(AC5)2-OSU) interMediate of 6-((+)-BiotinaMidohexanoylaMino)hexanoic acid N-hydroxysucciniMide ester Biotin-X-X-NHS, N-Succinimidyl N-[6-(biotinylamino)caproyl]-6-aminocaproate, 6-(Biotinamidocaproylamido)caproic acid N-hydroxysuccinimide ester
CAS	89889-52-1
EINECS	205-525-8

89889-52-1 - Physico-chemical Properties

Molecular Formula	C26H41N5O7S
Molar Mass	567.7
Density	1.29±0.1 g/cm3(Predicted)
Melting Point	147-151°C
Appearance	Morphological powder
pKa	13.90±0.40(Predicted)
Storage Condition	-20°C
Stability	Moisture Sensitive
MDL	MFCD00467154
Use	Biotinylation reagent incorporating an extended 14-atom spacer can reduce steric hindrance in binding avidin or streptavidin to some biotinylated compounds and increase sensitivity for detection. Typically coupled to primary amine in the pH range 6.5

89889-52-1 - Risk and Safety

WGK Germany	3
FLUKA BRAND F CODES	10-21
HS Code	29349990

89889-52-1 - Upstream Downstream Industry

Downstream Products

LC-LC(+)-Biotin

89889-52-1 - Nature

solubility	DMF: 25 mg/mL
BRN	8377428

Last Update：2024-04-10 22:29:15

89889-52-1 - Uses and synthesis methods

biological activity

Biotin-LC-LC-NHS are SMCC crosslinkers that can be used to label antibodies and small molecule drugs, such as paclitaxel.

in vitro study

Biotinylation of antibodies is accomplished by the reaction of Biotin-LC-LC-NHS (1 mg/mL in dimethyl formamide) with the protein in aqueous phase pH 7.4. The molar ratio of biotin to antibody in the labeling reaction was 10:1 (the final concentration of biotin was 70 μM) .

Last Update：2024-04-10 22:29:15