9-(Phenylmethyl)-9H-carbazole-3-carboxaldehyde
9-BENZYL-3-FORMYLCARBAZOLE
CAS: 54117-37-2
Molecular Formula: C20H15NO
9-(Phenylmethyl)-9H-carbazole-3-carboxaldehyde - Names and Identifiers
9-(Phenylmethyl)-9H-carbazole-3-carboxaldehyde - Physico-chemical Properties
| Molecular Formula | C20H15NO |
| Molar Mass | 285.34 |
| Density | 1.14±0.1 g/cm3(Predicted) |
| Melting Point | 134 °C |
| Boling Point | 444.9±37.0 °C(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Use | 9-benzyl carbazole -3-formaldehyde is useful as an intermediate in the synthesis of pharmaceuticals. For example, a carbazole compound can be prepared that significantly inhibits the activity of topoisomerase II. Cancer is a serious health problem in the 21st century. In the past few decades, people have been looking for effective treatment of cancer. In addition to surgery and radiotherapy, chemotherapy has been an important strategy for the treatment of cancer. Many drugs such as etoposide, camptothecin, paclitaxel are widely used in clinical anti-cancer therapy. About 50% of all anti-cancer drugs in clinical use act on human DNA topoisomerase. |
9-(Phenylmethyl)-9H-carbazole-3-carboxaldehyde - Introduction
9-BENZYL-3-FORMYLCARBAZOLE is an organic compound with the following properties:
Nature:
-Appearance: White or light yellow crystal powder
-Molecular formula: C14H11N3O
-Molecular weight: 237.26g/mol
-Melting point: About 211-212 ° C
-Solubility: Insoluble in water, soluble in organic solvents such as ethanol and methanol
Use:
-9-benzyl3-formylcarbazole is an effective antifungal agent, commonly used in the agricultural field to control fungal infections on crops, such as mold, Pythium, etc.
-It can also be used as a light stabilizer for dyes, plastics and polymers, which can improve their light resistance and weather resistance.
Preparation Method:
The preparation method of 9-benzyl3-formylcarbazole can be obtained by reacting benzylcarbazole with formaldehyde. The specific preparation method is that benzyl carbazole and formaldehyde are reacted under alkaline conditions, and the reaction product is acidified to obtain the final product.
Safety Information:
-9-benzyl3-formylcarbazole has low toxicity, but it is still necessary to pay attention to safe operation. Avoid direct contact with skin and eyes.
-During operation, good ventilation measures should be taken to avoid inhalation of the substance.
-Use personal protective equipment such as lab gloves, goggles and protective clothing.
-Do not discharge the substance into water bodies or the environment. Waste and residues should be properly disposed.
-During storage, 9-BENZYL-3-FORMYLCARBAZOLE should be stored in a sealed, dry, cool location, away from fire and flammable materials.
Nature:
-Appearance: White or light yellow crystal powder
-Molecular formula: C14H11N3O
-Molecular weight: 237.26g/mol
-Melting point: About 211-212 ° C
-Solubility: Insoluble in water, soluble in organic solvents such as ethanol and methanol
Use:
-9-benzyl3-formylcarbazole is an effective antifungal agent, commonly used in the agricultural field to control fungal infections on crops, such as mold, Pythium, etc.
-It can also be used as a light stabilizer for dyes, plastics and polymers, which can improve their light resistance and weather resistance.
Preparation Method:
The preparation method of 9-benzyl3-formylcarbazole can be obtained by reacting benzylcarbazole with formaldehyde. The specific preparation method is that benzyl carbazole and formaldehyde are reacted under alkaline conditions, and the reaction product is acidified to obtain the final product.
Safety Information:
-9-benzyl3-formylcarbazole has low toxicity, but it is still necessary to pay attention to safe operation. Avoid direct contact with skin and eyes.
-During operation, good ventilation measures should be taken to avoid inhalation of the substance.
-Use personal protective equipment such as lab gloves, goggles and protective clothing.
-Do not discharge the substance into water bodies or the environment. Waste and residues should be properly disposed.
-During storage, 9-BENZYL-3-FORMYLCARBAZOLE should be stored in a sealed, dry, cool location, away from fire and flammable materials.
Last Update：2024-04-10 22:29:15
9-(Phenylmethyl)-9H-carbazole-3-carboxaldehyde - Preparation
The preparation of 9-benzylcarbazole-3-formaldehyde is as follows:
1)1:1 equivalent of carbazole and benzyl bromide, DMF as solvent, add 5 equivalent of potassium carbonate, reaction at room temperature for 8h. After the reaction, recrystallized with absolute ethanol to obtain white solid carbazole-3-formaldehyde with a yield of 70-85%.
2) Under the ice bath at 0 ℃, the equal volume of N,N-dimethylformamide reacts with phosphorus oxychloride for 30min, then carbazole -3-formaldehyde, a compound dissolved in dichloromethane, is added and reacted at 90 ℃ for 6h. After the reaction, it was quenched with water, sodium hydroxide was neutralized to pH = 7, extracted with ethyl acetate and water, the organic phase was collected, and the white solid 9-benzylcarbazol-3-formaldehyde was purified by silica gel column with a yield of 77 ~ 89%.
Last Update：2024-04-10 22:29:15
9-(Phenylmethyl)-9H-carbazole-3-carboxaldehyde - Nature
| melting point | 134 °C |
| boiling point | 444.9±37.0 °C(Predicted) |
| density | 1.14±0.1 g/cm3(Predicted) |
| storage conditions | Inert atmosphere,Room Temperature |
Last Update：2024-04-09 19:04:55
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