9-Heptadecanol,9-Hydroxy-heptadecan
Heptadecan-9-ol
CAS: 624-08-8
Molecular Formula: C17H36O
9-Heptadecanol,9-Hydroxy-heptadecan - Names and Identifiers
| Name | Heptadecan-9-ol |
| Synonyms | C89-OH NISTC624088 9-HEPTADECANOL Heptadecan-9-ol 9-Heptadecanol,9-Hydroxy-heptadecan |
| CAS | 624-08-8 |
9-Heptadecanol,9-Hydroxy-heptadecan - Physico-chemical Properties
| Molecular Formula | C17H36O |
| Molar Mass | 256.47 |
| Density | 0.8406 (estimate) |
| Melting Point | 58.0 to 62.0 °C |
| Boling Point | 329.71°C (estimate) |
| pKa | 15.28±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.4262 |
| Use | Application 9-heptadecanol can be used to prepare ionizable cationic lipids for RNA delivery. Cationic lipids contain lipid nanoparticles that contain nucleic acids, preferably siRNA and mRNA. The lipid nanoparticles preferably increase the lifetime of the circulating RNA. Many different types of nucleic acids are currently being developed as therapeutic agents for the treatment of many diseases. With the development of these molecules, it has developed a need to prepare them in a stable and long shelf life form, and can be easily incorporated into anhydrous organic or anhydrous polar aprotic solvents, so that nucleic acids can be encapsulated without side reactions in polar aqueous solutions or non-polar solvents. The delivery of the therapeutic compound to the subject is important for its therapeutic effect, and can generally be hampered by the limited ability of the compound to reach the target cells and tissues. It is essential to improve the various delivery methods by which such compounds enter the target cells of the tissue. |
9-Heptadecanol,9-Hydroxy-heptadecan - Preparation
under the protection of argon, ethyl formate (7.4g,0.1mol) is dissolved in 200mL of anhydrous tetrahydrofuran. when the temperature is reduced to -78 ℃, n-octyl magnesium bromide (50mL,2mol/L) is slowly added, and gradually rises to room temperature after dropping, and the reaction is 12h. After the reaction is finished, it is treated with saturated ammonium chloride aqueous solution, extracted with dichloromethane, dried with MgSO4, and spun to obtain a white solid, namely 9-heptadecanol. The yield is 80%. 1HNMR, 13CNMR, MS and elemental analysis results show that the obtained compound is the target product.
Last Update：2024-04-10 22:29:15
9-Heptadecanol,9-Hydroxy-heptadecan - Reference Information
| application | 9-heptadecanol can be used to prepare ionizable cationic lipids for RNA delivery. Cationic lipids contain lipid nanoparticles that contain nucleic acids, preferably siRNA and mRNA. The lipid nanoparticles preferably increase the lifetime of the circulating RNA. Many different types of nucleic acids are currently being developed as therapeutic agents for the treatment of many diseases. With the development of these molecules, it has developed a need to prepare them in a stable and long shelf life form, and can be easily incorporated into anhydrous organic or anhydrous polar aprotic solvents, so that nucleic acids can be encapsulated without side reactions in polar aqueous solutions or non-polar solvents. The delivery of the therapeutic compound to the subject is important for its therapeutic effect, and can generally be hampered by the limited ability of the compound to reach the target cells and tissues. It is essential to improve the various delivery methods by which such compounds enter the target cells of the tissue. |
| preparation | under the protection of argon, ethyl formate (7.4g,0.1mol) is dissolved in 200mL anhydrous tetrahydrofuran, when the temperature is reduced to -78 ℃, n-octyl magnesium bromide (50mL,2mol/L) is slowly added, and gradually rises to room temperature after dropping, reaction 12h. After the reaction, it is treated with saturated ammonium chloride aqueous solution, extracted with dichloromethane, dried with MgSO4, and spun to obtain a white solid, namely 9-heptadecanol. The yield is 80%. 1HNMR, 13CNMR, MS and elemental analysis results show that the obtained compound is the target product. |
Last Update：2024-04-09 21:04:16
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CAS: 624-08-8
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CAS: 624-08-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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