9-hydroxy-7h-furo(3,2-g)(1)benzopyran-7-one
Xanthotol
CAS: 2009-24-7
Molecular Formula: C11H6O4
9-hydroxy-7h-furo(3,2-g)(1)benzopyran-7-one - Names and Identifiers
9-hydroxy-7h-furo(3,2-g)(1)benzopyran-7-one - Physico-chemical Properties
| Molecular Formula | C11H6O4 |
| Molar Mass | 202.16 |
| Density | 1.526±0.06 g/cm3(Predicted) |
| Melting Point | 250°C |
| Boling Point | 428.1±45.0 °C(Predicted) |
| Solubility | Soluble in chloroform, ethyl acetate, DMSO and other solvents, insoluble in water. |
| Appearance | Colorless crystal |
| Color | Light Beige to Dark Brown |
| pKa | 5.74±0.20(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD00017408 |
| Physical and Chemical Properties | Green powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from snake bed. |
9-hydroxy-7h-furo(3,2-g)(1)benzopyran-7-one - Risk and Safety
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | S20 - When using, do not eat or drink. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S24/25 - Avoid contact with skin and eyes. |
| UN IDs | 2810 |
| HS Code | 29329990 |
9-hydroxy-7h-furo(3,2-g)(1)benzopyran-7-one - Reference
| Reference Show more | 1. Zhu Chunlu, Wang Jing, Qiao Yuhang, et al. Study on serum pharmacochemistry of duliangwan [J]. Chinese Journal of Modern Applied Pharmacy, 37(4). 2. Peng Wen-hui, Zhao Xi-Juan, Chen Xi, Zhang Yao-Hai, Wang Cheng-Qiu, Zhao Qi-Yang, jiao bi-Ning. Rapid screening of bioactive components in lemon fruit by ultra performance liquid chromatography-quadrupole-Time of Flight high resolution mass spectrometry [J]. Food and Fermentation Industry, 2021,47(04):222-230 235-237. 3. [IF = 4.411] Liang Yang et al."New Insights into the Antibacterial Activity of Hydroxycoumarins against Ralstonia solanacearum." Molecules. 2016 Apr;21(4):468 4. [IF = 2.048] Wang Ji Ye et al."Network pharmacologic mechanisms of Vernonia antherelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes."Bmc Syst Biol. 2017 Dec;11(1):1-12 5. [IF=6.576] Li Guijie et al."Effects of Cold-Pressing and Hydrodistillation on the Active Non-volatile Components in Lemon Essential Oil and the Effects of the Resulting Oils on Aging-Related Oxidative Stress in Mice."Front Nutr. 2021 Jun;0:329 6. [IF=3.512] Yahong Chen et al."Identification of Potential Human Ryanodine Receptor 1 Agonists and Molecular Mechanisms of Natural Small-Molecule Phenols as Anxiolytics."Acs Omega. 2021;XXXX(XXX):XXX-XXX 7. [IF=5.645] Chao-Ran Li et al."LC-MS-based untargeted metabolomics reveals chemical differences of Cannabis leaves from different regions of China."Ind Crop Prod. 2022 Feb;176:114411 |
9-hydroxy-7h-furo(3,2-g)(1)benzopyran-7-one - Reference Information
| Source | Zanthoxylum bungeanum belongs to linear furan coumarin, and the substituent group at the fifth site is hydroxyl. Among the plant resources of traditional Chinese medicine, Zanthoxylum bungeanum is found in Umbelliferae, Rutaceae, Moraceae, Acanthaceae and Rhamnaceae. Umbelliferae and Rutaceae are the most common. Researchers generally extract natural pepper toxols from Umbelliferae plants. In the "Pharmacopoeia of the People's Republic of China", there are 8 kinds of Umbelliferae Chinese medicines in the 17 kinds of Umbelliferae family, including Cnidium Cnidium, Qianghuo, Mingdangshen root, Angelica dahurica, Ginseng, Fangfeng, Peucedanum, Baiyun flower root. Other Rutaceae traditional Chinese medicines, Fructus Aurantii, Fructus Aurantii, Coriander, Zanthoxylum bungeanum, Yellow skin, Rhamnaceae iron fence fruit and Andrographis paniculata of Acanthaceae all have Zanthoxylum bungeanum. The medicinal properties of traditional Chinese medicines in Umbelliferae and Rutaceae are mostly bitter and pungent, which also suggests that Zanthoxylum bungeanum may be an important factor in "bitter and pungent taste. Bitter drugs can relieve, strengthen, and pungent drugs can spread. From the perspective of medicinal properties-ingredients-efficacy, it is speculated that its pharmacological functions such as anti-tumor, anti-inflammatory and analgesic are in line with the characteristics of bitter and pungent drugs. |
| anti-tumor effect | Zanthoxylum bungeanum has the effect of inhibiting the proliferation of tumor cells. Zanthoxylum bungeanum has obvious inhibitory effect on the proliferation of hela- S3 cells cultured in vitro, but its effect is weaker than that of osthole. Zanthoxylum bungeanum has inhibitory effect not only on hela-S3 cells, but also on six other tumor cells such as human liver cancer cell lines SMMC- 7721,Hep G2, human lung cancer cell lines A- 549, human gastric cancer cell lines MKN- 45, human breast cancer cell lines MCF- 7, MDA- MB- 2317. Studies have reported that Zanthoxylum bungeanum has a better inhibitory effect on MCF- 7. |
| biological activity | Xanthotoxol (8-Hydroxysoralen) is a biologically active linear furan coumarin with strong pharmacological activities, such as anti-inflammatory, antioxidant, 5-HT antagonism and neuroprotection. |
| target | Human Endogenous Metabolite serotonin |
| chemical properties | green powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from snake bed. |
| use | prickly ash toxophenol has anti-inflammatory, antitussive, antiasthmatic and expectorant effects. Cytotoxicity has an inhibitory effect on the proliferation of HeLa cells. Antispasmodic, mutagenic, can cause DNA lethal damage under strong near ultraviolet light irradiation; inhibit plant growth; anti-arrhythmia. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: It has antiasthmatic, expectorant, anti-allergic effects, prevents osteoporosis caused by glucocorticoids, analgesia, hypoxia tolerance, anti-arrhythmia, etc. |
Last Update：2024-04-09 20:52:54
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Spot supply
Product Name: Xanthotoxol Visit Supplier Webpage Request for quotationCAS: 2009-24-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Xanthotol Visit Supplier Webpage Request for quotationCAS: 2009-24-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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