Name | Qstatin |
Synonyms | Qstatin 1H-Pyrazole, 1-[(5-bromo-2-thienyl)sulfonyl]- 1-((5-Bromothiophen-2-yl)sulfonyl)-1H-pyrazole |
CAS | 902688-24-8 |
Molecular Formula | C7H5BrN2O2S2 |
Molar Mass | 293.16 |
Density | 1.93±0.1 g/cm3(Predicted) |
Boling Point | 446.3±55.0 °C(Predicted) |
Solubility | DMSO : 83.33 mg/mL (284.25 mM; Need ultrasonic) |
pKa | -5.76±0.19(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
In vitro study | QStatin (0.001 μM-10 μM; 5 hours) inhibits SmcR activity measured by the RLU level for V. vulnificusWT (pBB1), reveals EC 50 of 208.9 nM. QStatin (5 μM-50 μM; 16 hours) reduces the activities of SmcR-activated virulence factors (protease and elastase) in V. vulnificus in a dose dependent manner. QStatin (5 μM-50 μM; 16 hours) has no effect on the cellular levels of SmcR, indicating that QStatin does not affect the expression or stability of SmcR. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.411 ml | 17.056 ml | 34.111 ml |
5 mM | 0.682 ml | 3.411 ml | 6.822 ml |
10 mM | 0.341 ml | 1.706 ml | 3.411 ml |
5 mM | 0.068 ml | 0.341 ml | 0.682 ml |