905274-26-2
tert-Butyl 5-iodoisoindoline-2-carboxylate
CAS: 905274-26-2
Molecular Formula: C13H16INO2
905274-26-2 - Names and Identifiers
| Name | tert-Butyl 5-iodoisoindoline-2-carboxylate |
| Synonyms | tert-Butyl 5-iodoisoindoline-2-carboxylate 2H-Isoindole-2-carboxylic acid, 1,3-dihydro-5-iodo-, 1,1-dimethylethyl ester |
| CAS | 905274-26-2 |
905274-26-2 - Physico-chemical Properties
| Molecular Formula | C13H16INO2 |
| Molar Mass | 345.18 |
| Density | 1.577±0.06 g/cm3(Predicted) |
| Boling Point | 373.5±42.0 °C(Predicted) |
| pKa | -1.69±0.20(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Sensitive | IRRITANT |
| MDL | MFCD11878369 |
905274-26-2 - Introduction
tert-Butyl is an organic compound with the chemical formula C14H18INO2. It is a solid with yellow to orange crystals. Such compounds are commonly used as intermediates and reagents in organic synthesis.
Due to the existence of iodine atoms, it has strong charge instability and can undergo electrophilic substitution reactions. It is often used in the synthesis of biologically active compounds in organic synthesis, and is involved in the construction of a variety of carbon-carbon and carbon-nitrogen bonds, which has important application value.
The preparation of tert-Butyl is usually carried out by alkali-acid reaction. First, an alkali metal carbonate is reacted with ethyl isoindole-2-carboxylate using a basic solvent to obtain a corresponding ester salt. Then, the carbonyl group in the ester salt is subjected to an iodination reaction by adding iodide to generate tert-Butyl.
Regarding safety information, tert-Butyl should be careful to avoid contact with skin and eyes during storage and handling. It may cause irritation and damage to the eyes, respiratory system and skin. Wear appropriate protective equipment and operate in a well-ventilated area. If ingested or inhaled, seek medical help immediately.
Due to the existence of iodine atoms, it has strong charge instability and can undergo electrophilic substitution reactions. It is often used in the synthesis of biologically active compounds in organic synthesis, and is involved in the construction of a variety of carbon-carbon and carbon-nitrogen bonds, which has important application value.
The preparation of tert-Butyl is usually carried out by alkali-acid reaction. First, an alkali metal carbonate is reacted with ethyl isoindole-2-carboxylate using a basic solvent to obtain a corresponding ester salt. Then, the carbonyl group in the ester salt is subjected to an iodination reaction by adding iodide to generate tert-Butyl.
Regarding safety information, tert-Butyl should be careful to avoid contact with skin and eyes during storage and handling. It may cause irritation and damage to the eyes, respiratory system and skin. Wear appropriate protective equipment and operate in a well-ventilated area. If ingested or inhaled, seek medical help immediately.
Last Update：2024-04-10 22:29:15
