909910-43-6
A 83-01
CAS: 909910-43-6
Molecular Formula: C25H19N5S
909910-43-6 - Names and Identifiers
909910-43-6 - Physico-chemical Properties
| Molecular Formula | C25H19N5S |
| Molar Mass | 421.52 |
| Density | 1.27±0.1 g/cm3(Predicted) |
| Melting Point | 111℃ |
| Boling Point | 590.0±60.0 °C(Predicted) |
| Solubility | DMSO: soluble5mg/mL, clear (warmed) |
| Appearance | powder |
| Color | white to beige |
| pKa | 8.77±0.70(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| In vitro study | A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, reduces the level of ALK-5-induced transcription with an IC 50 of 12 nM in Mv1Lu cells, also blocks the ALK4-TD and ALK7-TD induced transcription with IC 50 s of 45 nM and 7.5 nM in R4-2 cells, and weakly suppresses that induced by constitutively active ALK-6, ALK-2, ALK-3, and ALK-1. A 83-01 (0.03-10 µM) potently prevents the growth-inhibitory effects of TGF-β, and completely inhibits the effect at 3 µM. A 83-01 (1-10 µM) inhibits TGF-β-induced Smad activation in HaCaT cells. A 83-01 (1 µM) decreases cell motility, adhesion and invasion increased by TGF-β1 in HM-1 cells, but does not change cell proliferation. |
| In vivo study | A 83-01 (50, 150 and 500 μg/mouse, i.p.) significantly improves survival of the mice without body weight or neurobehavioral appearances. A 83-01 (0.5 mg/kg, i.p.) shows a significantly strong antitumor effect in mice bearing M109 cells. |
909910-43-6 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
909910-43-6 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.372 ml | 11.862 ml | 23.724 ml |
| 5 mM | 0.474 ml | 2.372 ml | 4.745 ml |
| 10 mM | 0.237 ml | 1.186 ml | 2.372 ml |
| 5 mM | 0.047 ml | 0.237 ml | 0.474 ml |
Last Update：2024-01-02 23:10:35
909910-43-6 - Introduction
A 83-01 (an isoquinazoline derivative) is A compound with A variety of properties and uses. The following is an introduction about A 83-01:
Nature:
A 83-01 is A solid compound with A chemical formula of cwww.tianyancha.com h₂ n₂ O₂ and A molecular weight of 288.30g/mol. It has a white or white-like color and can exist as a powder or in crystalline form.
Use:
A 83-01 has many applications in biomedical research. It is a potent inhibitor of TGF-beta (transforming growth factor beta) receptor kinase and can affect cell growth, proliferation and transformation by inhibiting the TGF-beta signaling pathway. Therefore, A 83-01 is often used in biomedical research, including the regulation of cell proliferation and differentiation, Cancer Research and stem cell culture and differentiation.
Preparation Method:
The preparation method of A 83-01 can be obtained through A multi-step synthesis, including the reaction of pyrrolidone derivatives and isocyanates. The specific synthesis process needs to be carried out under suitable laboratory conditions and in accordance with the relevant synthetic practice.
Safety Information:
A 83-01 is generally considered to have low toxicity when used and stored correctly. However, as a chemical, it can have potentially toxic and irritating effects on the human body. When using A 83-01, you should follow the laboratory practice and take necessary safety measures, such as wearing personal protective equipment (such as gloves, goggles, protective clothing, etc.), ensure good air circulation and ventilation in the laboratory. When handling and storing A 83-01, avoid contact with oxidants and flammable materials, and keep away from open flames. In case of any safety problems or accidents, professional guidance and handling should be sought immediately.
Nature:
A 83-01 is A solid compound with A chemical formula of cwww.tianyancha.com h₂ n₂ O₂ and A molecular weight of 288.30g/mol. It has a white or white-like color and can exist as a powder or in crystalline form.
Use:
A 83-01 has many applications in biomedical research. It is a potent inhibitor of TGF-beta (transforming growth factor beta) receptor kinase and can affect cell growth, proliferation and transformation by inhibiting the TGF-beta signaling pathway. Therefore, A 83-01 is often used in biomedical research, including the regulation of cell proliferation and differentiation, Cancer Research and stem cell culture and differentiation.
Preparation Method:
The preparation method of A 83-01 can be obtained through A multi-step synthesis, including the reaction of pyrrolidone derivatives and isocyanates. The specific synthesis process needs to be carried out under suitable laboratory conditions and in accordance with the relevant synthetic practice.
Safety Information:
A 83-01 is generally considered to have low toxicity when used and stored correctly. However, as a chemical, it can have potentially toxic and irritating effects on the human body. When using A 83-01, you should follow the laboratory practice and take necessary safety measures, such as wearing personal protective equipment (such as gloves, goggles, protective clothing, etc.), ensure good air circulation and ventilation in the laboratory. When handling and storing A 83-01, avoid contact with oxidants and flammable materials, and keep away from open flames. In case of any safety problems or accidents, professional guidance and handling should be sought immediately.
Last Update：2024-04-09 20:48:19
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Spot supply
Product Name: A 83-01 Visit Supplier Webpage Request for quotationCAS: 909910-43-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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