Production method | 16 α,17 α-epoxypregnan-4-ene-3, 11,20-triketone (I. e. 16 α,17 α,-epoxy-11-keto-based progesterone) can be used, condensed with ethylene glycol (ketonated at the 3,20-position), then reduce (11-ketone group and 4-position double bond), (11-position hydroxyl group) to eliminate the introduction of 9(11)-position double bond, (epoxy group) methyl magnesium bromide addition and hydrolysis to generate 17 α-hydroxy -16 β-methylpregnan-4-9 (11)-diene -3,20-diketone, and then (1,2-position) dehydrogenation, (21-position) iodination, (21-position iodine with potassium acetate) replacement to prepare the product. |