913822-46-5
SC75741
CAS: 913822-46-5
Molecular Formula: C29H23N7O2S2
913822-46-5 - Names and Identifiers
913822-46-5 - Physico-chemical Properties
| Molecular Formula | C29H23N7O2S2 |
| Molar Mass | 565.67 |
| Density | 1.483±0.06 g/cm3(Predicted) |
| Solubility | DMSO : ≥ 125 mg/mL (220.98 mM) |
| Appearance | powder |
| Color | white to beige |
| pKa | 9.11±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Use | SC75741 is a widespread and potent NF-κB inhibitor with an IC50 of 200 nM for p65. SC75741 can block influenza viruses replication. SC75741 inhibits caspase activation and blocks nuclear output of caspase-mediated viral ribonucleoprotein (viralribonucleoproteins) by impairing DNA binding of NF-κB subunit p65, resulting in decreased expression of cytokines, chemokines and pro-apoptotic factors. |
| Target | NF-κB |
| In vitro study | SC75741 showed immunosuppressive activity by inhibiting proliferation of human PBMC with an IC50 of 2.2 μm. SC75741 Inhibits Influenza A and B by inhibiting the NF-κB-mediated signaling pathway at the transcriptional level Virus. In addition, SC75741 showed a high barrier effect on the development of antiviral variants. SC75741 showed immunosuppressive activity by inhibiting proliferation of human PBMC with an IC50 of 2.2 μm. SC75741 Inhibits Influenza A and B by inhibiting the NF-κB-mediated signaling pathway at the transcriptional level Virus. In addition, SC75741 showed a high barrier effect on the development of antiviral variants. |
| In vivo study | After injection of H5N1 Virus, SC75741 (15 mg/kg, I. P.) reduced Virus replication and cytokine expression in the lungs of mice. after injection of H5N1 Virus, SC75741 (15 mg/kg, I. P.) reduced Virus replication and cytokine expression in the lungs of mice. |
913822-46-5 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.768 ml | 8.839 ml | 17.678 ml |
| 5 mM | 0.354 ml | 1.768 ml | 3.536 ml |
| 10 mM | 0.177 ml | 0.884 ml | 1.768 ml |
| 5 mM | 0.035 ml | 0.177 ml | 0.354 ml |
Last Update：2024-01-02 23:10:35
913822-46-5 - Reference Information
| biological activity | SC75741 is a potent NF-κB inhibitor with an EC50 of 200 nM. SC75741 is a potent NF-κB inhibitor with an EC50 of 200 nM. SC75741 is effective in blocking the spread of influenza Virus. |
| in vitro study | SC75741 showed immunosuppressive activity by inhibiting human PBMC proliferation with an IC50 of 2.2 μm. SC75741 Inhibits Influenza A and B by inhibiting the NF-κB-mediated signaling pathway at the transcriptional level Virus. In addition, SC75741 showed a high barrier effect on the development of antiviral variants. SC75741 showed immunosuppressive activity by inhibiting proliferation of human PBMC with an IC50 of 2.2 μm. SC75741 Inhibits Influenza A and B by inhibiting the NF-κB-mediated signaling pathway at the transcriptional level Virus. In addition, SC75741 showed a high barrier effect on the development of antiviral variants. |
| in vivo study | after injection of H5N1 Virus, SC75741 (15 mg/kg, I. P.) reduces Virus replication and cytokine expression in the mouse lung. after injection of H5N1 Virus, SC75741 (15 mg/kg, I. P.) reduced Virus replication and cytokine expression in the lungs of mice. |
| characteristic | NF-Δb selective inhibitor. |
| Target | TargetValue NF-Δb (Cell-based NF-Δb reporter gene assay) 200 nM(EC50) |
| Target | Value |
| NF-κB (Cell-based NF-κB reporter gene assay) | 200 nM(EC50) |
Last Update：2024-04-09 21:32:00
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Featured ProductsSpot supply
Product Name: SC75741 Visit Supplier Webpage Request for quotationCAS: 913822-46-5
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: SC75741 Visit Supplier Webpage Request for quotationCAS: 913822-46-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: SC75741 Visit Supplier Webpage Request for quotationCAS: 913822-46-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: SC75741 Visit Supplier Webpage Request for quotationCAS: 913822-46-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
913822-46-5
1997387-43-5
27374-25-0
2-(4-methyl-1,3-thiazol-2-yl)acetonitrile
2-(2,4-二氯苯基)-2,2-二氟乙酸
10510-77-7
1222800-79-4
499-75-2
861928-23-6
3471-31-6
1997387-43-5
27374-25-0
2-(4-methyl-1,3-thiazol-2-yl)acetonitrile
2-(2,4-二氯苯基)-2,2-二氟乙酸
10510-77-7
1222800-79-4
499-75-2
861928-23-6
3471-31-6