92-39-7
2-Chlorophenothiazine
CAS: 92-39-7
Molecular Formula: C12H8ClNS
92-39-7 - Names and Identifiers
| Name | 2-Chlorophenothiazine |
| Synonyms | Chlorophenothiazine TIMTEC-BB SBB003255 3-CHLOROPHENOTHIAZINE 2-Chlorophenothiazine 2-CHLOROPHENOTHIAZINE 2-CHLOROTHIODIPHENYLAMINE 10H-Phenothiazine,2-chloro- CyaMeMazine Chloro IMpurity |
| CAS | 92-39-7 |
| EINECS | 202-152-5 |
| InChI | InChI=1/C12H8ClNS/c13-8-5-6-12-10(7-8)14-9-3-1-2-4-11(9)15-12/h1-7,14H |
92-39-7 - Physico-chemical Properties
| Molecular Formula | C12H8ClNS |
| Molar Mass | 233.72 |
| Density | 1.2350 (rough estimate) |
| Melting Point | 195-200 °C (lit.) |
| Boling Point | 395.7±31.0 °C(Predicted) |
| Flash Point | 193.1°C |
| Solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| Vapor Presure | 1.81E-06mmHg at 25°C |
| Appearance | Green gray powder |
| Color | Pale Beige to Beige |
| BRN | 176587 |
| pKa | -2.28±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.6100 (estimate) |
| MDL | MFCD00005016 |
| Physical and Chemical Properties | Melting Point: 197-202°C |
| Use | Used as an intermediate of the drug chlorpromazine hydrochloride |
92-39-7 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| RTECS | SN7580000 |
| TSCA | Yes |
| HS Code | 2934300000 |
92-39-7 - Reference Information
| LogP | 3.28 |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | as an intermediate of the drug chlorpromazine hydrochloride pharmaceutical intermediate for the preparation of chlorpromazine and perphenazine. |
| production method | is obtained by cyclization of M-chlorodiphenylamine. M-chlorodiphenylamine and sulfur were added to the reaction Pan, the temperature was raised to 70 ° C., and iodine was added. The temperature is raised to 120 ℃, the hydrogen sulfide is discharged under reduced pressure, and then the temperature is raised to 168-172 ℃ for 0.5h. After cooling, chlorobenzene and activated carbon were added and heated to reflux for 1H. The filtrate was filtered while hot and cooled to 15 °c for crystallization. The filtrate was filtered, and the filter cake was washed once with chlorobenzene and ethanol to obtain 2-chlorophenothiazine. |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | intravenous-mouse LD50: 18 mg/kg |
| flammability hazard characteristics | flammable, decomposes toxic chlorides during combustion, sulfur oxide and nitrogen oxide gases |
| storage and transportation characteristics | The warehouse is low temperature, ventilated and dry, and stored separately from food raw materials |
| extinguishing agent | water, carbon dioxide, dry powder, sand |
Last Update：2024-04-09 02:00:12
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