92262-58-3
VALROCEMIDE
CAS: 92262-58-3
Molecular Formula: C10H20N2O2
92262-58-3 - Names and Identifiers
| Name | VALROCEMIDE |
| Synonyms | TV 1901 VALROCEMIDE Valrocemide(TV1901) N-Valproylglycinamide Valrocemide (TV1901,VGD)) N-(2-Amino-2-oxoethyl)-2-propylpentanamide |
| CAS | 92262-58-3 |
92262-58-3 - Physico-chemical Properties
| Molecular Formula | C10H20N2O2 |
| Molar Mass | 200.28 |
| Density | 0.997 |
| Storage Condition | 2-8℃ |
| In vivo study | In mice, valrocemide affords complete protection against maximal electroshock-, pentylenetetrazole-, picrotoxin-, and bicuculline-induced seizures and 6-Hz “psychomotor” seizures with median effective dose (ED 50 ) values of 151, 132, 275, 248, and 237 mg/kg, respectively. Valrocemide is also effective in preventing sound-induced seizures in Frings audiogenic-seizure susceptible mice (ED 50 , 52 mg/kg). The median neurotoxic dose in mice is 332 mg/kg. After oral administration to rats, valrocemide is active in the MES test, with an ED 50 of 73 mg/kg, and the median neurotoxic dose is 1,000 mg/kg. Intraperitoneal administration of 300 mg/kg of valrocemide to hippocampal kindled Sprague–Dawley rats block generalized seizures and shorten the afterdischarge duration significantly. Valrocemide also provides complete protection from focal seizures in the corneally kindled rats (ED 50 , 161 mg/kg). |
92262-58-3 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.993 ml | 24.965 ml | 49.93 ml |
| 5 mM | 0.999 ml | 4.993 ml | 9.986 ml |
| 10 mM | 0.499 ml | 2.497 ml | 4.993 ml |
| 5 mM | 0.1 ml | 0.499 ml | 0.999 ml |
Last Update：2024-01-02 23:10:35
92262-58-3 - Reference Information
| biological activity | Valrocemide(TV1901) is a promising anti-epileptic drug candidate, has a wide range of anticonvulsant activity. |
Last Update：2024-04-09 21:54:55
Supplier List
Spot supply
Product Name: VALROCEMIDE Visit Supplier Webpage Request for quotationCAS: 92262-58-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: VALROCEMIDE Visit Supplier Webpage Request for quotationCAS: 92262-58-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History