923-32-0
DL-Cystine
CAS: 923-32-0
Molecular Formula: C6H12N2O4S2
923-32-0 - Names and Identifiers
| Name | DL-Cystine |
| Synonyms | CYSTINE CCRIS 8599 DL-Cystine DL-CYSTINE Cystine, DL- JACS-923-32-0 (H-DL-CYS-OH)2 Cystine DL-form DL-CYSTINE CRYSTALLINE beta,beta'-Dithioalanine, dl- 3,3'-DITHIO-BIS-(2-AMINOPROPIONIC ACID) 3,3'-Dithiobis(2-aminopropanoic acid), dl- |
| CAS | 923-32-0 |
| EINECS | 213-094-5 |
| InChI | InChI=1/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1 |
923-32-0 - Physico-chemical Properties
| Molecular Formula | C6H12N2O4S2 |
| Molar Mass | 240.3 |
| Density | 1.358 (estimate) |
| Melting Point | 227°C (dec.)(lit.) |
| Boling Point | 468.2±45.0 °C(Predicted) |
| Flash Point | 237°C |
| Water Solubility | Soluble in dilute acid and alkali solution, highly soluble in water, not soluble in alcohol. |
| Solubility | 1 M HCl: soluble |
| Vapor Presure | 4.62E-10mmHg at 25°C |
| Appearance | Powder |
| Color | White |
| Merck | 14,2782 |
| BRN | 1728095 |
| pKa | 2.1(at 35℃) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.6000 (estimate) |
| MDL | MFCD00084652 |
| Physical and Chemical Properties | White hexagonal plate crystal or white crystalline powder. Soluble in dilute acid and alkali solution, extremely difficult to dissolve in water, insoluble in ethanol. |
| Use | Used as a Biochemical reagent |
923-32-0 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29309014 |
923-32-0 - Standard
Authoritative Data Verified Data
This product is L-3,3. Dithiobis (2-aminopropionic acid). Calculated as dry product, containing no less than 98.5% of C6H12N204S2.
Last Update：2024-01-02 23:10:35
923-32-0 - Trait
Authoritative Data Verified Data
- This product is white crystal or crystalline powder.
- This product is almost insoluble in water or ethanol; Dissolved in dilute hydrochloric acid or sodium hydroxide solution.
specific rotation
take this product, precision weighing, plus lmol/L hydrochloric acid solution dissolved and quantitatively diluted to make a solution containing about 20mg per lml, determined according to law (General 0621), the specific rotation is from one to 215 ° to one to 230 °.
Last Update：2022-01-01 15:38:26
923-32-0 - Differential diagnosis
Authoritative Data Verified Data
- the appropriate amount of this product and the cystine reference product were dissolved and diluted by adding 2% ammonia solution to prepare a solution containing about 10 mg per 1 ml, which was used as the test solution and the reference solution. According to the chromatographic condition test under other amino acids, the position and color of the main spot of the test solution should be the same as that of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 1036).
Last Update：2022-01-01 15:38:26
923-32-0 - Exam
Authoritative Data Verified Data
acidity
take this product 1.og, add water 100ml, fully shake, according to the law (General 0631),pH value should be 5.0~6.5.
transmittance of solution
take this product 1.og, add lmol /L hydrochloric acid solution 20ml to dissolve, according to the ultraviolet-visible spectrophotometry (General rule 0401), measure the transmittance at 430nm wavelength, not less than 98.0%.
chloride
take 0.50g of this product, Add 10ml of dilute nitric acid to dissolve, add water to make 50ml, take 25ml, check according to law (General rule 0801), and compare with the control solution made of ML of standard sodium chloride solution, no more concentrated (0.02%).
sulfate
take 0.70g of this product, add 5ml of dilute hydrochloric acid, shake to dissolve, add water to make 40ml, check according to law (General rule 0802), not more concentrated (0.02%) than the control solution made from of standard potassium sulfate solution plus 5ml of dilute hydrochloric acid.
other amino acids
take an appropriate amount of this product, add 2% ammonia solution to dissolve and dilute to make a solution containing about 10 mg per lml as a test solution; Take 1ml for precision measurement and put it in a 200ml measuring flask, dilute with 2% ammonia solution to the scale, shake well, as a control solution; Take the appropriate amount of cystine reference substance and Arginine hydrochloride reference substance, and put them in the same measuring flask, add 2% ammonia solution to dissolve and dilute to make a solution containing about 10 mg of cystine and 1 mg of Arginine hydrochloride per 1ml, respectively, as a system-suitable solution. According to the thin layer chromatography (General 0502) test, draw 2ul of each of the above three solutions, respectively point on the same silica gel G thin layer plate, with isopropanol-concentrated ammonia solution (7:3) as the developing solvent, expand, dry, spray with 0.2% ninhydrin in n-butanol-glacial acetic acid solution (95:5), and heat at 80°C until spots appear, and examine immediately. The control solution should show a clear spot, and the system applicable solution should show two completely separated spots. If the test solution shows impurity spots, its color shall not be deeper (0.5%) than that of the main spot of the control solution, and shall not exceed 1.
loss on drying
take this product, dry at 105°C for 3 hours, loss of weight shall not exceed 0.2% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Iron Salt
The residue left under the item of ignition residue was added with 1 ml of nitric acid, dried on a water bath, and dissolved with 4ml of dilute hydrochloric acid at a slight temperature, and then transferred to a 50ml Nessler colorimetric tube, inspection according to law (General rule 0807), and standard iron solution 1.0ml of the control solution should not be deeper (0.001%).
Heavy metals
take this product 1.Og, inspection according to law (General Principles 0821 second law), containing heavy metals shall not exceed 10 parts per million.
arsenic salt
take this product 2. G, add water 23ml, and then add hydrochloric acid 5ml to dissolve, check according to law (General rule 0822 first law), should comply with the provisions (0.0001%).
Last Update：2022-01-01 15:38:27
923-32-0 - Content determination
Authoritative Data Verified Data
take about 80mg of this product, weigh it accurately, put it in the iodine bottle, add 2ml of sodium hydroxide test solution and 10ml of water, shake and dissolve it, then add 1Oml of potassium bromide solution (20-eo), add 50ml of potassium bromate titration solution (0.016 67mol/L) and 15ml of dilute hydrochloric acid, pack, place in an ice bath in the dark for 10 minutes, add 1.5g of potassium iodide, shake for minutes, with sodium thiosulfate titration solution (0.1 mol/L) titration, to the near end point, add starch indicator 2ml, continue titration to blue disappeared, and the titration results are corrected by blank test. Each 1 ml of potassium bromate titration solution (0.01667mol/L) is equivalent to 2.403mg of C6H12N204S2.
Last Update：2022-01-01 15:38:28
923-32-0 - Category
Authoritative Data Verified Data
amino acid drugs.
Last Update：2022-01-01 15:38:28
923-32-0 - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 15:38:28
923-32-0 - CystineTablets
Authoritative Data Verified Data
This product contains cystine (C6H12N204S2) should be labeled the amount of 90.0% to 110.0%.
trait
This product is white tablet.
identification
- Take 2 tablets of this product, grind, take appropriate amount of fine powder (about 2mg equivalent to cystine), add 2% sodium acetate solution 3ml and ninhydrin about 1 mg, heat, the solution shows blue purple.
- take an appropriate amount of fine powder of this product (about equivalent to cystine lOOmg), put it in a 10ml measuring flask, add an appropriate amount of 12% ammonia solution to dissolve cystine, dilute it to the scale, filter it, the filtrate was taken according to the identification (1) Test under cystine, and the same results were shown.
examination
should be in accordance with the relevant provisions under The tablet item (General rule 0101).
Content determination
Take 20 tablets of this product, precise weighing, fine grinding, precise weighing appropriate amount (about 80mg equivalent to cystine), according to the method under the determination of cystine content, that is obtained.
category
cystine.
specification
(l)25mg (2)50mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 15:38:29
923-32-0 - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| Use | used in medicine, food, cosmetics and other industries used in biochemical research. used as Biochemical reagent |
| production method | with L-cystine as raw material, reflux in 6mol/L hydrochloric acid for several hours, activated carbon after concentration, ammonia neutralization cystine crude, and then recrystallized pure. |
Last Update：2024-04-09 15:16:53
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