92619-25-5
Valine, N-methyl-N-[(phenylmethoxy)carbonyl]-
CAS: 92619-25-5
Molecular Formula: C14H19NO4
92619-25-5 - Names and Identifiers
| Name | Valine, N-methyl-N-[(phenylmethoxy)carbonyl]- |
| Synonyms | Cbz-N-methyl-DL-valine Cbz-N-Methyl-DL-valine Valine, N-methyl-N-[(phenylmethoxy)carbonyl]- |
| CAS | 92619-25-5 |
92619-25-5 - Physico-chemical Properties
| Molecular Formula | C14H19NO4 |
| Molar Mass | 265.3 |
92619-25-5 - Introduction
Valine, N-methyl-N-[(phenylmethoxy)carbonyl]-is an amino acid derivative. Its chemical formula is C17H21NO5 and its relative molecular mass is 323.36g/mol.
The following are some of the properties of Valine, N-methyl-N-[(phenylmethoxy)carbonyl]:
1. Appearance: white or almost white crystalline powder.
2. melting point: about 140-145 ℃.
3. Solubility: Good solubility in common organic solvents such as ethanol and ethyl acetate.
Valine, N-methyl-N-[(phenylmethoxy)carbonyl]-is mainly used as an intermediate in biochemical research, especially in the field of peptide synthesis. It can be used as a protective group to protect the amino group in amino acids and play a key role in the synthesis of specific peptide chains.
The method for preparing Valine, N-methyl-N-[(phenylmethoxy)carbonyl]-is as follows:
First, valine is reacted with N-methyl-anisole acid chloride (Cbz-Cl) to produce Valine, N-methyl-N-[(phenylmethoxy)carbonyl]-ester. The reaction conditions are generally carried out in an anhydrous organic solvent with the addition of an acidic catalyst.
The resulting ester is then reacted with hydrochloric acid to give Valine, N-methyl-N-[(phenylmethoxy)carbonyl]-.
When using and handling Valine, N-methyl-N-[(phenylmethoxy)carbonyl]-, you need to pay attention to the following safety information:
1. Avoid direct contact with skin and eyes and wear appropriate personal protective equipment.
2. Avoid inhaling dust and ensure that the operation is carried out in a well-ventilated place.
3. Store in a sealed container, away from heat sources and open flames.
4. During use, avoid contact with oxidants and strong acids.
5. If accidentally ingested or inhaled, seek medical attention immediately.
Note: DL-Valine is an unnatural amino acid that has two enantiomers (D-and L-) at its stereogenic center. The preparation of Valine, N-methyl-N-[(phenylmethoxy)carbonyl]-involves the synthesis of stereoselectivity-based reactions.
The following are some of the properties of Valine, N-methyl-N-[(phenylmethoxy)carbonyl]:
1. Appearance: white or almost white crystalline powder.
2. melting point: about 140-145 ℃.
3. Solubility: Good solubility in common organic solvents such as ethanol and ethyl acetate.
Valine, N-methyl-N-[(phenylmethoxy)carbonyl]-is mainly used as an intermediate in biochemical research, especially in the field of peptide synthesis. It can be used as a protective group to protect the amino group in amino acids and play a key role in the synthesis of specific peptide chains.
The method for preparing Valine, N-methyl-N-[(phenylmethoxy)carbonyl]-is as follows:
First, valine is reacted with N-methyl-anisole acid chloride (Cbz-Cl) to produce Valine, N-methyl-N-[(phenylmethoxy)carbonyl]-ester. The reaction conditions are generally carried out in an anhydrous organic solvent with the addition of an acidic catalyst.
The resulting ester is then reacted with hydrochloric acid to give Valine, N-methyl-N-[(phenylmethoxy)carbonyl]-.
When using and handling Valine, N-methyl-N-[(phenylmethoxy)carbonyl]-, you need to pay attention to the following safety information:
1. Avoid direct contact with skin and eyes and wear appropriate personal protective equipment.
2. Avoid inhaling dust and ensure that the operation is carried out in a well-ventilated place.
3. Store in a sealed container, away from heat sources and open flames.
4. During use, avoid contact with oxidants and strong acids.
5. If accidentally ingested or inhaled, seek medical attention immediately.
Note: DL-Valine is an unnatural amino acid that has two enantiomers (D-and L-) at its stereogenic center. The preparation of Valine, N-methyl-N-[(phenylmethoxy)carbonyl]-involves the synthesis of stereoselectivity-based reactions.
Last Update：2024-04-10 22:29:15
