926927-61-9

Name	Motolimod
Synonyms	VTX2337 VTX-378 VTX 378 VTX 2337 VTX-2337 MOTOLIMOD Motolimod Obicetrapib Motolimod(VTX-2337) 2-amino-n,n-dipropyl-8-[4-(pyrrolidine-1-carbonyl)phenyl]-3h-1-benzazepine-4-carboxamide 2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide
CAS	926927-61-9

Molecular Formula	C28H34N4O2
Molar Mass	458.6
Density	1.19±0.1 g/cm3(Predicted)
Boling Point	718.7±70.0 °C(Predicted)
Solubility	10 mM in DMSO
Appearance	solid
Color	Off-white or pale yellow
pKa	2.47±0.40(Predicted)
Storage Condition	-20°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
In vitro study	VTX-2337 stimulated the production of TNFα and IL-12 In PBMCs with EC50 of 140 nM and 120 nM, respectively. In monocytes and mDCs, VTX-2337 selectively induced TNFα and IL-12 production by NF-κB activation. VTX-2337 also stimulates IFNγ production in NK cells, increases cytolysin function in myogenic NK cells, and enhances ADCC.
In vivo study	In a mouse model of ovarian cancer, TX-2337 enhances the effect of liposomal doxorubicin (PLD).

Last Update：2024-01-02 23:10:35

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Product Name: Motolimod Visit Supplier Webpage Request for quotation
CAS: 926927-61-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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926927-61-9

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