928774-43-0
PF-3716556
CAS: 928774-43-0
Molecular Formula: C22H26N4O3
928774-43-0 - Names and Identifiers
928774-43-0 - Physico-chemical Properties
| Molecular Formula | C22H26N4O3 |
| Molar Mass | 394.47 |
| Density | 1.30 |
| Melting Point | 143-145°C |
| Solubility | DMSO 79 mg/mL Water <1 mg/mL Ethanol 79 mg/mL |
| Appearance | powder |
| Color | white to tan |
| pKa | 14.18±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| MDL | MFCD19690947 |
| Use | A highly selective H ,K -ATPase inhibitor that is more potent in acidic conditions. |
| In vitro study | PF-03716556 is a potent, selective acid-Pump-resistant antagonist that inhibits porcine H in ion-permeation and ion-dense assays |
| In vivo study | PF-03716556 inhibits gastric acid secretion in rat and dog animal models. PF-03716556 has a long-lasting effect, with a maximum effect of 30 minutes in a single dose, and there is no obvious signal of resistance after 5 consecutive days of injection. |
928774-43-0 - Risk and Safety
| WGK Germany | 3 |
928774-43-0 - Introduction
PF-3716556 is an effective and selective P-CAB potassium ion competitive acid inhibitor. In ion permeation and ion intensive detection, it inhibits pig H ,K -ATPase activity, inhibits gastric acid secretion, has no activity on Na ,K -ATPas, and is used to treat gastroesophageal reflux diseases.
Last Update：2022-10-16 17:41:52
928774-43-0 - Reference Information
| Biological activity | PF-3716556 is an effective and selective P-CAB potassium ion competitive acid inhibitor. In ion permeation and ion intensive detection, it inhibits pig H ,K -ATPase activity, inhibits gastric acid secretion, has no effect on Na ,K -ATPas, and is used to treat gastroesophageal reflux disease. |
| Target | Value |
| H+/K+-ATPase | ~6.5(pIC50) |
Last Update：2024-04-09 20:02:46
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Product Name: PF-3716556 Visit Supplier Webpage Request for quotation
CAS: 928774-43-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 928774-43-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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