933-67-5
7-Methylindole
CAS: 933-67-5
Molecular Formula: C9H9N
933-67-5 - Names and Identifiers
| Name | 7-Methylindole |
| Synonyms | 7-METHYINDOLE 7-Methylindol 7-Metlylindole 7-METHYLINDOLE 7-Methylindole Indole, 7-methyl- 7-METHYL-1H-INDOLE 7-Methyl-1H-indole 1H-Indole, 7-methyl- |
| CAS | 933-67-5 |
| EINECS | 213-270-1 |
| InChI | InChI=1/C9H9N/c1-7-3-2-4-8-5-6-10-9(7)8/h2-6,10H,1H3 |
933-67-5 - Physico-chemical Properties
| Molecular Formula | C9H9N |
| Molar Mass | 131.17 |
| Density | 1.0202 |
| Melting Point | 80-84 °C (lit.) |
| Boling Point | 266 °C (lit.) |
| Flash Point | 266°C |
| Water Solubility | negligible |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Appearance | Red crystal |
| Color | Off-White to Pale Beige |
| BRN | 111088 |
| pKa | 17.30±0.30(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Sensitive | Light Sensitive |
| Refractive Index | 1.6070 (estimate) |
| MDL | MFCD00005684 |
| Use | Used as a reagent for organic synthesis |
933-67-5 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R21/22 - Harmful in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 13 |
| HS Code | 29309090 |
| Hazard Note | Light Sensitive/Irritant |
933-67-5 - Introduction
Insoluble in water, soluble in dichloromethane, methanol and acetonitrile.
Last Update：2022-10-16 17:30:15
933-67-5 - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| Application | 7-methylindole is an indole derivative. Indole and its derivatives are important organic raw materials and chemical products. They are widely used in the preparation of pesticides, pharmaceuticals, dyes, spices, plant growth regulators and feed additives. 7-methylindole is a reactant for the synthesis of α-amino amides, which are present in a variety of biologically active compounds. |
| preparation | weigh 10mmol of 2-methylaniline and mmol of AlCl3 in a reaction flask, dissolve in of tetrahydrofuran, to the reaction flask was added 30mmol of ethylene oxide at 0 °c. The reaction was maintained at 0 °c and stirred for 10H. After isolation and purification, n-hydroxyethyl-2-methylaniline was obtained (yield 83.1%). Weigh 5mmol of n-hydroxyethyl-2-methylaniline and 7.5mmol of 2-methylaniline in a reaction flask, dissolve in 200ml of acetonitrile, add Sn/activated carbon supported catalyst, the reaction was stopped after complete reaction of n-hydroxyethyl-2-methylaniline by TLC. After isolation and purification, 7-methylindole was obtained (yield 64.3%). |
| Use | as a reagent in organic synthesis pharmaceutical intermediate |
Last Update：2024-04-09 21:04:16
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