93718-83-3 - Names and Identifiers
Name | NSC 95397
|
Synonyms | NSC 95397 Cdc25 Inhibitor IV, NSC 95397 2,3-BIS[(2-HYDROXYETHYL)THIO]-1,4-NAPHTHOQUINONE 2,3-BIS(2-HYDROXYETHYLTHIO)-1,4-NAPHTHALENEDIONE 2,3-BIS[(2-HYDROXYETHYL)THIOL]-1,4-NAPHTHOQUINONE 1,4-Naphthalenedione, 2,3-bis[(2-hydroxyethyl)thio]-
|
CAS | 93718-83-3
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93718-83-3 - Physico-chemical Properties
Molecular Formula | C14H14O4S2
|
Molar Mass | 310.39 |
Solubility | DMSO: 16 mg/mL |
Appearance | Orange solid |
Color | orange, solid |
Storage Condition | -20°C |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
MDL | MFCD04040032 |
In vitro study | NSC 95397 (0, 10, and 20 µM; 24 hour) decreases the cell viability of three colon cancer cell lines SW480, SW620, and DLD-1 in a concentration-dependent manner. NSC 95397(10 μM; 24 hour) upregulates p21 while downregulates CDK4 and CDK6 were d in all three colon cancer cell lines SW480, SW620, and DLD-1 cells. NSC 95397 (10 μM; 24 hour) reduces the phosphorylation of retinoblastoma protein (Rb) on Ser795 and Ser807/811. NSC 95397 (20 μM; 24 hours) significantly increases cleaved caspase-9, -3, -7 and PARP levels. NSC 95397 (10 μM; 6 hours) enhances the phosphorylation of its downstream ERK1/2 at Thr202/Tyr 204. Cell Viability Assay Cell Line: Human colon cancer cell lines, SW480, SW620, and DLD-1 Concentration: 0, 10, and 20 µM Incubation Time: 24 hours Result: The IC 50 values of NSC 95397 for the cell growth of SW480, SW620, and DLD-1 cells were 9.9, 14.1 and 18.6 μM, respectively. Western Blot Analysis Cell Line: SW480, SW620, and DLD-1 cells Concentration: 10 μM Incubation Time: 24 hours Result: p21 was upregulated while CDK4 and CDK6 were downregulated. Rduced the phosphorylation of Rb on Ser795 and Ser807/811 |
93718-83-3 - Risk and Safety
Hazard Symbols | Xi - Irritant
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WGK Germany | 3 |
Hazard Class | IRRITANT |
93718-83-3 - Preparation solution concentration reference
| 1mg | 5mg | 10mg |
---|
1 mM | 3.222 ml | 16.109 ml | 32.218 ml |
5 mM | 0.644 ml | 3.222 ml | 6.444 ml |
10 mM | 0.322 ml | 1.611 ml | 3.222 ml |
5 mM | 0.064 ml | 0.322 ml | 0.644 ml |
Last Update:2024-01-02 23:10:35
93718-83-3 - Introduction
The NSC 95397 is a compound whose chemical name is N-(3-bromophenyl) propane -1, 3-diamine. The following is a description of some general Properties, Uses, methods, and safety information about NSC 95397:
Nature:
-Appearance: NSC 95397 appears as a solid state, commonly white to light yellow crystals.
-Solubility: Soluble in some organic solvents such as dimethyl sulfoxide (DMSO), methanol and ethanol.
Use:
-Research Tools: NSC 95397 are commonly used as experimental tools in biochemical and pharmaceutical research. It is widely used to study cell proliferation, apoptosis, cancer and other related fields.
-Anti-cancer drugs: Some studies have shown that NSC 95397 have the effect of inhibiting cell growth and inducing apoptosis, so it is considered as a potential candidate for anti-cancer drugs.
Preparation Method:
The preparation method of-NSC 95397 is more complicated and generally requires organic synthesis methods for synthesis. The specific chemical synthesis route may vary according to different research needs.
Safety Information:
-The NSC 95397 has limited safety information and toxicity data. However, as a chemical substance, proper use and handling is necessary. Laboratory safety practices should be followed when using NSC 95397.
-It is strongly recommended that appropriate personal protective equipment, such as lab gloves, safety glasses and lab coats, be worn when using and handling NSC 95397.
-Avoid contact of NSC 95397 with skin, eyes and respiratory tract, as well as other possible routes of exposure.
-Before use, it is recommended to carefully read the safety data sheet of the NSC 95397 to understand more detailed safety information and Operation suggestions.
Last Update:2024-04-09 20:45:29