Name | D,L-Lactide S |
Synonyms | Lactide dilactide DL-Lactide DL-Dilactide D,L-Lactide S |
CAS | 95-96-5 |
EINECS | 202-468-3 |
InChI | InChI=1/C6H8O4/c1-3-5(7)10-4(2)6(8)9-3/h3-4H,1-2H3 |
Molecular Formula | C6H8O4 |
Molar Mass | 144.13 |
Density | 1.186±0.06 g/cm3(Predicted) |
Melting Point | 116-119℃ |
Boling Point | 138℃(8 torr) |
Flash Point | 180°C |
Solubility | Soluble in chloroform and methanol. Slightly soluble in benzene. |
Appearance | Form Crystalline Powder, color White |
Storage Condition | 2-8°C |
Sensitive | Easily absorbing moisture |
MDL | MFCD00011685 |
Use | Use the racemic lactide is subjected to an enzymatic alcoholysis reaction catalyzed by commercially available Novozym(R)435 to produce alkyl (R)-lactate and alkyl (S,S)-lactyl lactate, with very high yield and enantiomeric purity. |
Hazard Symbols | Xi - Irritant |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
WGK Germany | 2 |
RTECS | JH1100000 |
TSCA | Yes |
HS Code | 29322090 |
Downstream Products | polylactic acid and its copolymer Potassium lactate |
solubility | Soluble in chloroform and methanol. Slightly soluble in benzene. |
sensitivity | Moisture Sensitive |
BRN | 82121 |
NIST chemical information | 1,4-Dioxane-2,5-dione, 3,6-dimethyl-(95-96-5) |
EPA chemical information | 1,4-Dioxane-2,5-dione, 3,6-dimethyl- (95-96-5) |
introduction
Lactide is a colorless transparent flake or needle-like crystal with a melting point of 93-95°C, easily soluble in chloroform, ethanol, and insoluble in water. Easy to hydrolyze, easy to polymerize. It can be used for the production of medical high polylactic acid, cyclic esterifying agent.
market
At present, domestic polylactic acid production enterprises mainly rely on imports of lactide. The international companies capable of producing lactide are Nature Works and Total Koben. Since the former is not sold to the outside world, Chinese enterprises mainly import lactide from Total-Koben. However, as the global demand for high-quality lactide continues to grow, Total Koben is also gradually shrinking its external sales.
production technology
lactide is produced from lactic acid raw materials, mainly by condensation polymerization of lactic acid to generate lactic acid oligomers, and then depolymerization of lactic acid oligomers to generate lactide.
The whole process needs to be carried out under high temperature, negative pressure and catalytic conditions. During this period, in order to improve the overall yield, the unreactants need to be refluxed and reused, and finally qualified lactide products are obtained through certain purification methods. The lactide production process mainly includes polycondensation, depolymerization cyclization and purification of several units