96568-04-6

96568-04-6 - Names and Identifiers

Name	Ethyl-2,6-Dichloro-5-Fluoro Pyridine-3-Acetoacetate
Synonyms	Nicotinylacetate Ethyl 2,6-Dichloro-5-Fluoro 2,6-Dichloro-5-Fluoronicothinic acetale 2,6-Dichloro-5-Fluoro nicotinoyl acetate Ethyl-2,6-Dichloro-5-Fluoro-Nicotinylacetae Ethyl 2,6-dichloro-5-fluornicotinoylacetate Ethyl-6-Dichloro-5-Fluoropyridine-3-Acetoacetare Ethyl 2,6-dichloro-5-fluoropyridine-3-acetoacetate Ethyl 2,6-dichloro-5-fluoro-pyridine-3-acetoacetate Ethyl 2,6-Dichloro-5-Fluoro Pyridine-3-Acetoacetate Ethyl-2,6-Dichloro-5-Fluoro Pyridine-3-Acetoacetate Ethyl 2,6-dichloro-5-fluoro-b-oxo-3-pyridinepropanoate Ethyl 2,6-dichloro-5-fluoro-β-oxo-3-pyridine propionate Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate ethyl 2-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxobutanoate Ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate Ethyl 3-[2,6-dichloro-5-fluoro-(3-pyridiyl)]-3-oxopropanoate 3-Pyridinepropanoic acid, 2,6-dichloro-5-fluoro-b-oxo-, ethyl ester
CAS	96568-04-6
EINECS	627-012-4
InChI	InChI=1/C10H8Cl2FNO3/c1-2-17-8(16)4-7(15)5-3-6(13)10(12)14-9(5)11/h3H,2,4H2,1H3
InChIKey	IEUHWNLWVMLHHC-UHFFFAOYSA-N

96568-04-6 - Physico-chemical Properties

Molecular Formula	C10H8Cl2FNO3
Molar Mass	280.08
Density	1.4602 (estimate)
Melting Point	68-72 °C (lit.)
Boling Point	349.9±37.0 °C(Predicted)
Flash Point	165.4°C
Solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Vapor Presure	4.57E-05mmHg at 25°C
Appearance	Crystalline powder
Color	White to Off-White
pKa	9.43±0.50(Predicted)
Storage Condition	Sealed in dry,Store in freezer, under -20°C
Refractive Index	1.524
MDL	MFCD00799535

96568-04-6 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
HS Code	29333990
Hazard Note	Irritant

96568-04-6 - Introduction

Ethyl-2,6-Dichloro-5-Fluoro Pyridine-3-Acetoacetate is an organic compound with a chemical formula of C11H10Cl2FNO3 and a molecular weight of 279.11. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: Ethyl-2,6-Dichloro-5-Fluoro Pyridine-3-Acetoacetate is a white or off-white crystalline solid with a pungent odor.
-Melting point: Its melting point range is 45-48 degrees Celsius.
-Solubility: It can be dissolved in organic solvents such as alcohols, ethers and ketones, and slightly soluble in water.

Use:
- Ethyl-2,6-Dichloro-5-Fluoro Pyridine-3-Acetoacetate are often used in the synthesis of biologically active heterocyclic compounds in the pharmaceutical field.
-It is one of the important intermediates in biodiversity research.
-In addition, it can also be used as a catalyst and a functional group transfer reagent in organic synthesis.

Preparation Method:
Ethyl-2,6-Dichloro-5-Fluoro Pyridine-3-Acetoacetate can be synthesized by the following steps:
1. The ethyl acetoacetate and 2,6-dichloro-5-fluoropyridine are reacted under acidic conditions.
2. The reaction mixture is neutralized under basic conditions to form Ethyl-2,6-Dichloro-5-Fluoro Pyridine-3-Acetoacetate.
3. Finally, the product is purified and collected by crystallization and other methods.

Safety Information:
- Ethyl-2,6-Dichloro-5-Fluoro Pyridine-3-Acetoacetate is an irritating compound that may cause skin and eye irritation when contacted. Therefore, it is necessary to follow proper laboratory procedures and wear appropriate personal protective equipment.
-It should be stored in a dry, cool place, away from fire and oxidants, avoid direct sunlight exposure.
-When handling and disposing of the compound, the relevant environmental and safety regulations should be followed, and care should be taken to prevent it from causing harm to the environment.

Last Update：2024-04-09 20:52:54