970-74-1
(-)-epigallocatechin
CAS: 970-74-1
Molecular Formula: C15H14O7
970-74-1 - Names and Identifiers
| Name | (-)-epigallocatechin |
| Synonyms | EGC epigallocatechol (-)-epigallocatechol (-)-epigallocatechin antiscurvyfactorc(sub2) 3,3',4',5,5',7-flavanhexol professional supplier Epigallocatechin 970-74-1 2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol (2R,3R)-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol 5,7-triol,3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-2h-1-benzopyran-(2r-cis |
| CAS | 970-74-1 |
| EINECS | 619-254-4 |
| InChI | InChI=1/C15H14O7/c16-7-3-9(17)8-5-12(20)15(22-13(8)4-7)6-1-10(18)14(21)11(19)2-6/h1-4,12,15-21H,5H2/t12-,15-/m1/s1 |
| InChIKey | XMOCLSLCDHWDHP-IUODEOHRSA-N |
970-74-1 - Physico-chemical Properties
| Molecular Formula | C15H14O7 |
| Molar Mass | 306.27 |
| Density | 1.695±0.06 g/cm3(Predicted) |
| Melting Point | 208-210°C |
| Boling Point | 685.6±55.0 °C(Predicted) |
| Specific Rotation(α) | -50 º (c=0.04, EtOH) |
| Flash Point | 368.5°C |
| Solubility | Soluble in methanol, ethanol, insoluble in petroleum ether and chloroform. |
| Vapor Presure | 9.69E-20mmHg at 25°C |
| Appearance | White powder |
| Color | White to Light Beige |
| Maximum wavelength(λmax) | ['278nm(MeOH)(lit.)'] |
| pKa | 9.02±0.15(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensitive | Sensitive to heat |
| Refractive Index | 1.775 |
| MDL | MFCD00075939 |
| Physical and Chemical Properties | It is derived from green tea. |
| In vitro study | (-)-Epigallocatechin (EGC) is a potent inhibitor of amyloidogenic cystatin I66Q amyloid fibril formation in vitro. Computational analysis suggests that (-)-Epigallocatechin prevents amyloidogenic cystatin fibril formation by stabilizing the molecule in its native-like state as opposed to redirecting aggregation to disordered, amorphous aggregates [1]. Combined curcumin and EGCG treatment reduced the cancer stem-like Cluster of differentiation 44 (CD44)-positive cell population. Western blot and immunoprecipitation analyses revealed that curcumin and (-)-Epigallocatechin (EGC) specifically inhibited STAT3 phosphorylation and STAT3-NFkB interaction was retained [2]. (-)-Epigallocatechin (EGC) exhibits a MIC and MBC of 5 μg/mL and 20 μg/mL respectively and effectively eradicated E. faecalis biofilms. (-)-Epigallocatechin induces the formation of hydroxyl radicals in E. faecalis. The addition of DIP protected E. faecalis against EGCG-mediated antibacterial effects. At sub-MIC, (-)-Epigallocatechin induces significant down-regulation of E. faecalis virulence genes [3]. |
970-74-1 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | KB5100000 |
| FLUKA BRAND F CODES | 3-10 |
| HS Code | 29329990 |
970-74-1 - Reference Information
| Use | (-)-epigallocatechin for assay identification/determination, pharmacological activity screening; for content determination/identification/pharmacological experiments. Pharmacological Efficacy: has a good antioxidant activity, this year's study of the compound also has a certain anti-tumor activity. green tea polyphenols. Anti-cancer agent. The antioxidant activity was lower than that of EGCG. |
| Green tea extract | Epigallocatechin (epigallocatechin) is a polyphenol compound that is naturally present in the dry leaves of Theaceae plant tea, it is the main body of physiologically active substances in green tea extract. epigallocatechin has the following physiological effects: 1. Epigallocatechin has an antioxidant effect and can protect biofilms from oxidative damage induced by free radicals. 2, epigallocatechin catechin has hypolipidemic effect, can prevent atherosclerosis and cardiovascular disease and other biological functions, and even considered stronger than vitamin E. 3, epigallocatechin has anticancer activity, activity is slightly lower than that of epigallocatechin gallate. |
| biological activity | (-)-Epigallocatechin (Epigallocatechin) is the most abundant flavonoid in green tea, can bind the unfolded polypeptide and prevent conversion to amyloid fibers. |
Last Update：2024-04-09 21:01:54
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Featured ProductsMultiple SpecificationsSpot supply
Product Name: (-)-Epigallocatechin/EGC Visit Supplier Webpage Request for quotationCAS: 970-74-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Catechin Impurity 2 ((-)-Epigallocatechin) Visit Supplier Webpage Request for quotationCAS: 970-74-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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