97207-47-1
Meisoindigo
CAS: 97207-47-1
Molecular Formula: C17H12N2O2
97207-47-1 - Names and Identifiers
| Name | Meisoindigo |
| Synonyms | Dian III Natura-α Meisoindigo MEISOINDIGO Methylisoindigotin N-methylisoindigotin 1-METHYL-3,3'-BIINDOLE-2,2'(1H,1'H)-DIONE 3-(1,2-dihydro-2-oxo-3h-indol-3-ylidene)-1,3-dihydro-1-methyl-2h-indol-2-one Meisoindigo 3-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-2H-indol-2-one |
| CAS | 97207-47-1 |
| EINECS | 200-256-5 |
97207-47-1 - Physico-chemical Properties
| Molecular Formula | C17H12N2O2 |
| Molar Mass | 276.29 |
| Melting Point | 236-237°C |
| Appearance | powder to crystal |
| Color | Orange to Brown to Dark red |
| Storage Condition | Sealed in dry,Room Temperature |
97207-47-1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.619 ml | 18.097 ml | 36.194 ml |
| 5 mM | 0.724 ml | 3.619 ml | 7.239 ml |
| 10 mM | 0.362 ml | 1.81 ml | 3.619 ml |
| 5 mM | 0.072 ml | 0.362 ml | 0.724 ml |
Last Update：2024-01-02 23:10:35
97207-47-1 - Reference Information
| biological activity | Meisoindigo (Dian III) is a derivative of Indirubin (HY-N0117), can cause acute myeloid leukemia (AML) cell cycle arrest in G0/G1 phase, and induce apoptosis. Meisoindigo has high anti-tumor activity. |
| Cell Line: | HL-60, NB4, U937 leukemic cell lines HL-60 cells HL-60 cells HL-60 cells |
| Concentration: | 5, 10, 15, 20 μM 10 μM 5, 10 μM 5, 10 μM |
| Incubation Time: | For 24 hours For 24 hours For 24 hours For 24 hours |
| Result: | Inhibited growth of the AML cell lines in a dose- and time-dependent manner. Induced apoptosis of acute myeloid leukemia. Caused cell-cycle arrest, with more cells in sub-G1 and G0/G1 phases and fewer cells in the S phase, in a dose-dependent manner. Increased the cleaved caspase-3 and pro-apoptotic Bak, and decreased Bcl-2 and Bcl-xL levels in HL-60 cells. Had anti-leukemic activity in vivo. |
| Animal Model: | NOD/SCID mice, 6-8 weeks old, with HL-60 leukemic cells |
| Dosage: | 50, 100, 150 mg/kg |
| Administration: | IP; daily; for 14 days |
Last Update：2024-04-10 22:29:15
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