99119-73-0
Kushenol C
CAS: 99119-73-0
Molecular Formula: C25H26O7
99119-73-0 - Names and Identifiers
99119-73-0 - Physico-chemical Properties
| Molecular Formula | C25H26O7 |
| Molar Mass | 438.47 |
| Appearance | Yellow powder |
| Storage Condition | 2-8℃ |
| In vitro study | Kushenol C dose-dependently suppresses the production of inflammatory mediators, including NO, PGE2, IL-6, IL1β, MCP-1, and IFN-β in LPS-stimulated RAW264.7 macrophages. Kushenol C (50-100 µM;) significantly decreases the phosphorylation of both STAT1 molecules and STAT6 in a dose-dependent manner in LPS-stimulated RAW264.7 cells. Kushenol C upregulates the expression of HO-1 and its activities in the LPS-stimulated RAW264.7 macrophages. In HaCaT cells, Kushenol C prevents DNA damage and cell death by upregulating the endogenous antioxidant defense system involving glutathione, superoxide dismutase, and catalase, which prevents reactive oxygen species production from tert-butyl hydroperoxide (tBHP)-induced oxidative stress in HaCaT cells. Kushenol C inhibits BChE and AChE with IC 50 s of 54.86 and 33.13 µM. |
99119-73-0 - Reference Information
| biological activity | Kushenol C was isolated from the roots of Sophora flavescens ait has anti-inflammatory and antioxidant effects. Kushenol C inhibits BACE1 with an IC50 value of 5.45 μm. |
Last Update：2024-04-09 21:54:55
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CAS: 99119-73-0
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CAS: 99119-73-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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